ID A0A2C9JMK1_BIOGL Unreviewed; 1097 AA.
AC A0A2C9JMK1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0008006|Google:ProtNLM};
GN Name=106060200 {ECO:0000313|EnsemblMetazoa:BGLB004886-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB004886-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB004886-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB004886-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
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DR RefSeq; XP_013073453.1; XM_013217999.1.
DR AlphaFoldDB; A0A2C9JMK1; -.
DR STRING; 6526.A0A2C9JMK1; -.
DR EnsemblMetazoa; BGLB004886-RB; BGLB004886-PB; BGLB004886.
DR KEGG; bgt:106060200; -.
DR VEuPathDB; VectorBase:BGLB004886; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF604; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF12810; Gly_rich; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 510..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..190
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 607..878
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 902..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 641
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1097 AA; 122445 MW; C844EC607FCD5059 CRC64;
MKDLDECDFP SGRCLWYNVQ SKQDSDFLWE KTKGDIQMEV FNRLHVIQSN TSLTTIETWD
SKSYLQVQLR RKWRLSEAIL RSVSFEPNYI SRHCQIGFWY LIDDDLKSAV LKLELIQLKN
GVKTKPVLLW KSPDNPLAAS GNIFQKVVVS LPLKLTNISF MLQFKTYFTN ANDYGQVALY
QVAMSPDCFH TVLSLSSCGQ TGSTGPTQDM CDREYDHEDL VRVVEDGHFS GAQMWTVPES
MFYRIEAFGS RGGRLNDDHG LQRESLGARV ETKFYFEKGE AIYFVIGQAG EDECPNDIND
DGLKFPPYCT ISSDASDNWR KGGPGGGGAT IVFKIVNDTK PVALLIAGGG SGQKFRNVSD
TVLEQTDKDL LMSGLETDIL LSRSLNGLPP CSQMTNGHKY WMASGGYGLG GGSCGDRGLG
GPLIAGLATS GKSYIHPSSL FSDMHSGFHN GEGLLEIFVD TCSCPYHCMW LDNDDVYKPT
CLCPSNKTSR QQCKDVLETS REGLDLTSNF VLMILISGLV SVVFSLCCVG LYLRRQAVKA
RHPTSIKKIA SFFCPCVHFY NPPVSIGGHT LPQIQRPPTV MHANPNYDRI DLNNSEQALK
EIPRKHLKLM SELGQGAFGE VYYGLLSNVP MVDGDLPVAV KTLPQVCTEQ MEMDFLMEAV
IVSKFNHPNI VKFIGVCFNE RPHYLVLELL EGGDLKSFLL QARPKWEQPS QLTVLDLLRL
SLDIARGCQH LEEKHFIHRD IAARNCLLST KGPHRIAKIA DFGMARDIYR SDYYKKSGKA
LLPVKWMPPE AFLDGVFSVK TDVWSFGILM WEVFSLGHMP YPGCSNEEVM NLVAQGGRLE
SPGGCPSAVF DIMVSCWNVL PEDRPNFSLI IASLERRLQD DDLATRGLPV FYVAPIVNTR
SPRLQERPPS SPHPRSVTSR GVIHPSESNI GPHIASDGYL EPLLSFNTRS VFNEGLYQTS
ENIQAKSAQK KTPTLTRDSG GGRAEQNKAM IKTRTPRVFY KTGSSYQPFN DAAASESLLQ
FETEEPPLEK NGIRLSAELN NDVRNPILGC DNDSDKTGQR ERFSLDDLKI PSVVALPEKS
QKKKSYTHFP RHSSNKY
//
