ID A0A2C9JN24_BIOGL Unreviewed; 1474 AA.
AC A0A2C9JN24;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Latrophilin Cirl {ECO:0000256|ARBA:ARBA00015543};
GN Name=106060681 {ECO:0000313|EnsemblMetazoa:BGLB005088-PG};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB005088-PG, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB005088-PG}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB005088-PG};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBUNIT: Forms a heterodimer, consisting of a large extracellular
CC region non-covalently linked to a seven-transmembrane moiety.
CC {ECO:0000256|ARBA:ARBA00011834}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_013074109.1; XM_013218655.1.
DR STRING; 6526.A0A2C9JN24; -.
DR EnsemblMetazoa; BGLB005088-RG; BGLB005088-PG; BGLB005088.
DR KEGG; bgt:106060681; -.
DR VEuPathDB; VectorBase:BGLB005088; -.
DR OrthoDB; 1114672at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15440; 7tmB2_latrophilin-like_invertebrate; 1.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR048072; 7tmB2_latrophilin-like.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF347; LATROPHILIN CIRL; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 835..858
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 870..890
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 902..925
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 937..957
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 977..1003
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1045..1068
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1074..1096
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..112
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 417..471
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 833..1098
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 316..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1359..1434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1474 AA; 164339 MW; 47EC56FAED35849F CRC64;
MGALLPSWND PHTTPKPPYI NSMVALNSTS IQINWTVEVP VITVAVYWTP VNVSNPKTVF
VTLDGKTRQT GSTSFVLNGL KPNTTYAIFL KPFLKNTNGP PTHTVNVTTL PDENQNDNSR
IQVRLNSHNA QNISGISLSN GSLDSSLSSS VSRNEGTKMG SSREIVRNIT LLKQPALVAK
KINDKRLEAM GNDMSTSSRL QEFVQKEEVE IFRKPNTSVS RHSEMYNNYN QKTILRAMNY
TSLHEYWRYL LSLWSGTNNS MSTTKSPITD FSTARLSTTS TVPSAVLPGS DEGSQSTFIP
DEYSYSISNS SLTVNAEQSK LSNHESTYES PHGNTTTHKP HTDRVFPLFT IKPEPVDHRR
TTPKKYFPAT ASTRTTTLSV STHKSPSPTL TPGLGWITPD EERPPPDIIQ DIDRRVCPRE
AKHGLAWPEI GFGQRYEQLC PGKLNGIAAW TCTELGWESS GPDISNCYSQ WLRDIQILVD
DLDRHRVVPM QSRLGKGNVD VIMSSLNEKV LEEEVIPGDI KRTILNIIPK LLQEFKEEVD
LETPINRPIR MKMFRRGYVS VGSNLLKEKH VKSWKSLTKQ DRQKAATSLL LSIENFGFES
ARFIEVGSRE REVASNIVVE VERVDSSKIK EDVTFPARNP PESRTIEEDR MFLTSRGYGP
GVEWAEITDT ITIPSINLQM EAGVTDIVFT LYKNLEDLIP PQLNIVTPLS HEINSHFNSG
TIRDNNKANA APQLVVNSNV VSASINGTRQ RRKLRRPVQF TLQHKTVVHN AVPICSFWNI
DISSSTGKWA SDGCNVVDTN ATHTTCSCNH LTNFALLMDV TGVKLSEESE LALRVITYVG
CIISIVCLLL SWITFMVFKN LQCDRNTIHK NLVLCLLLAE IVFLAGIAQT EPKFLCSLIA
GSLHYLFLGA FAWMCLEGVQ LYVMLIEVFE QERSRLIWYY LFGYGVPAVI VSISAGIYHQ
GYGTDRHCWL TTERSFIWAF VGPALAVMLV NIVMLGIAIY VMCRHTNMSA NTKERSKVTK
FSMSESLSSM ETFASPKLRF PDLPAWLKGA MVLVVLLGLT WLLGVLYLNK ESEIIAYLFT
ILNSLQGMFI FIFHCIKNEK VQKEYRKVAR RTAWLPNCIR VNYGGYNGVA SSSPIPSTGS
GNYLSRLFGP GKRKRSEVST NSSAKPFLSQ DNHRQSDVEF SSSRDASSAP VSLNGYVYTP
GFTSTQYPVV SQSSLKGAPN RMLAPPSQLA PCCETDCAGE LSEYLDCSVV DSEFVSEYCR
HNMQVSMEQK RYSTESEDSQ IVPNSHNLKP LDNDNLSTLS MASSSRKPSS LVSSLAGSEQ
KLVLNNFPRE GATSDPKLNL NQYIIPTSKK VQTNNLNANA AGEPRSASMN KLTKPAASLS
SIPESEHSPQ HSSTPNIQFS PDRGGRSRRE PVSDYEELSP SSTIDSPSSI QSSLPNLDML
TIDCEHGDHD YNRRRHSSET EIQFSPFRFT ATEC
//
