ID A0A2C9JN38_BIOGL Unreviewed; 550 AA.
AC A0A2C9JN38;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=mRNA m(6)A methyltransferase {ECO:0000256|ARBA:ARBA00012160};
DE EC=2.1.1.348 {ECO:0000256|ARBA:ARBA00012160};
GN Name=106060772 {ECO:0000313|EnsemblMetazoa:BGLB005122-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB005122-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB005122-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB005122-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-
CC methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;
CC Evidence={ECO:0000256|ARBA:ARBA00036277};
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC ProRule:PRU00489}.
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DR RefSeq; XP_013074228.1; XM_013218774.1.
DR AlphaFoldDB; A0A2C9JN38; -.
DR STRING; 6526.A0A2C9JN38; -.
DR EnsemblMetazoa; BGLB005122-RB; BGLB005122-PB; BGLB005122.
DR KEGG; bgt:106060772; -.
DR VEuPathDB; VectorBase:BGLB005122; -.
DR OrthoDB; 179166at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0016422; F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0001734; F:mRNA (N6-adenosine)-methyltransferase activity; IEA:UniProt.
DR InterPro; IPR025848; MT-A70.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12829; N6-ADENOSINE-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12829:SF2; N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF05063; MT-A70; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51143; MT_A70; 1.
DR PROSITE; PS51563; SAM_MTA70L_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 168..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 62942 MW; F79195B297C1476C CRC64;
MTVTKALITT TSTISTIKPL PRENIQVTLD PEVEKKLLMV LCDISLDIPS DSKGRLLKLL
PCLGIASRHQ WFGFRVFLLL GGEPAKINEP LLSKAYKFRR LLLSVITAHP TQNMAEKLFE
MHAFGRTFKE VCITKTHYHK IHRNFDRLNC KFIGSKQAFR HYKGTDQKKR KCSDDEDDAE
VSSKQSRTTA PESGDIESLL SMQSTKEREE KKLNEEIQAL LVTQTAKEQY LVEKFKSRGG
PQLQEFCQCG TREECLRSNP EGANCKRLHF KKIIKKHTDE SLGDCSFLNT CFHMDMCKYV
HYEIDYPPKT LPSTDFMKKE LSLGKLSSEI SDDGSVQMFP PQWIQCDLRY FDMSTLGKCA
VVMADPPWDI HMELPYGTMG DNEMRQLDIP GLQDDGFIFL WVTGRAMELG RECLELWGYK
RVDEIIWVKT NQLQRIIRTG RTGHWLNHGK EHCLVGVKGN PKGVNKGMDC DVIVAEVRAT
SHKPDEIYGI IERLSPGTRK VELFGRPHNV QPNWITLGNQ LEGVRLKDPD IVKLFREKYP
DGNCMGPPKK
//
