ID   A0A2C9JRG1_BIOGL        Unreviewed;      1036 AA.
AC   A0A2C9JRG1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Peptidase M14 carboxypeptidase A domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=106064887 {ECO:0000313|EnsemblMetazoa:BGLB006836-PB};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB006836-PB, ECO:0000313|Proteomes:UP000076420};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGLB006836-PB}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB006836-PB};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M14 family.
CC       {ECO:0000256|ARBA:ARBA00005988}.
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DR   RefSeq; XP_013078980.1; XM_013223526.1.
DR   AlphaFoldDB; A0A2C9JRG1; -.
DR   STRING; 6526.A0A2C9JRG1; -.
DR   EnsemblMetazoa; BGLB006836-RB; BGLB006836-PB; BGLB006836.
DR   KEGG; bgt:106064887; -.
DR   VEuPathDB; VectorBase:BGLB006836; -.
DR   OrthoDB; 168164at2759; -.
DR   Proteomes; UP000076420; Unassembled WGS sequence.
DR   GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd06907; M14_AGBL2-3_like; 1.
DR   Gene3D; 2.60.40.3120; -; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR040626; Pepdidase_M14_N.
DR   InterPro; IPR000834; Peptidase_M14.
DR   PANTHER; PTHR12756; CYTOSOLIC CARBOXYPEPTIDASE; 1.
DR   PANTHER; PTHR12756:SF45; CYTOSOLIC CARBOXYPEPTIDASE NNA1; 1.
DR   Pfam; PF18027; Pepdidase_M14_N; 1.
DR   Pfam; PF00246; Peptidase_M14; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
FT   DOMAIN          209..294
FT                   /note="Cytosolic carboxypeptidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18027"
FT   DOMAIN          362..595
FT                   /note="Peptidase M14 carboxypeptidase A"
FT                   /evidence="ECO:0000259|Pfam:PF00246"
FT   REGION          652..732
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          867..896
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          986..1010
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        694..719
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        881..896
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1036 AA;  119626 MW;  4EFDE39FA38E2047 CRC64;
     MMPGEDLCDD DYYGINPYES FMKKHLQHYG YYTGRNQNYK HHFKHYEEWE KNYGYTMSSE
     SSEDSDSDTD DDKACDSKLQ EDLLKTTQLI YSCGESGKMV PRLREPRSLY ALNKELGPQQ
     AARWPADLQV INERIKHIQT IPTEPEPFYK QTGFEKCPMV RGEANGGKVV FSYEANSSFF
     MKSRVGGSRN GCDQCSISLE SENDTTLIFE SRFESGNLGK AVQVGERDYE LWLRHDLYTN
     KHTQWFYFRV SNTRADVEYR FTIVNFMKSD SLYNDGMKPV MYSEKEAELN KVGWIRAGNN
     IKYYKNNLRY EMGKGERYYY SMTWTIQFKH DRDTVYFSHC YPYTYTDLQN YLLDLTNDPI
     KSRICKQRVL CRTLAGNLVY VITITSASQN PEDMKHKKAV VVTSRVHPGE SNSSWMLKGF
     LDFVTSSSPD AKLLRDSFIF KVVPMLNPDG VIVGNYRCSL TGRDLNRNYK TALKDAYPSV
     FHTKQMIRKL LLERDVIVYC DLHGHSRRQN VFIYGCEQPH RSNKRFNERI FPSMLNRNTP
     EKFCYDSCKF KVQKSKEGTG RVVMWNMGIM NSYTMEATFC GSSLGKKKGF HFNQRDFEMM
     GYHFCDTLLD YCDPDMTKCD QILFELKQKH HMMVLAKMAE KGLQVEDFPE VDMSTDTESS
     DDGSDSSISD GPPVHLQFTA PKPKKKKLRS KREREKLHKE EARKTTPVQE DKKMRNNQVK
     PLKPDNGKAM KYSTNIPKRA RSLDDRTNSG IPVFVQERFE EKQQKKHEYL EALTAAYINN
     NIPIVTDPAF VKLDNNYMKG ELDNELITMA ASEEADLKSD KRTVFGAESP KPMTVMTRQP
     SKIAMATTDI WSSEPVIHFR YSGKNSEFLN SHPHPEPSQP RPSQAAGSEV PQSNGEALTD
     SARFQSVFRE LDLHRITPKW LQEEASRIYA RRGDDSPFKI SRIFGRREVA SSETSVEDIL
     KSSLTHSASS SLARRKHKPH LLEVSAAQQR QTETLSHDRM SSIKTHPNPF NEISEASRAG
     EDYFIISHTL IHKQPG
//