ID A0A2C9JSY8_BIOGL Unreviewed; 3309 AA.
AC A0A2C9JSY8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:BGLB007552-PB};
GN Name=106066853 {ECO:0000313|EnsemblMetazoa:BGLB007552-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB007552-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB007552-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB007552-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_013081404.1; XM_013225950.1.
DR EnsemblMetazoa; BGLB007552-RB; BGLB007552-PB; BGLB007552.
DR VEuPathDB; VectorBase:BGLB007552; -.
DR OrthoDB; 2964592at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd01450; vWFA_subfamily_ECM; 13.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 15.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF70; PH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF00092; VWA; 15.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00327; VWA; 15.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF53300; vWA-like; 15.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS50234; VWFA; 15.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}.
FT DOMAIN 56..231
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 269..444
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 478..653
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 691..866
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 904..1079
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1117..1292
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1326..1501
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1535..1710
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1731..1906
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2012..2191
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2226..2401
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2408..2444
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2452..2630
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2633..2669
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2677..2854
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2857..2893
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2901..3078
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 3085..3121
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3129..3301
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1918..2007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2191..2217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..678
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..891
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1918..2000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2196..2216
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2434..2443
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2659..2668
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2883..2892
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3111..3120
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3309 AA; 364299 MW; 013630E86526F870 CRC64;
MNKNNPTRKP CADQKKNKVS ENGTPLSFDK TDETIAYPNK NNPTRKPKGC AGAKLDLVFV
LDASTSVTEP NFELMKDFVK DFLLDADIDG GNVRVGVVIY SDADYVQFQL NTYAKKADVY
NAIDDIPYRY GSTNTADALK TMRSVMFTAG NGDRSDVNNV AVVVTDGVSN INSRRTVPEA
EQARAEGIHI YAIGIGLTDT KELDGIASKP VDENRFAVQE FTELRDLRHK VFSALCSTLP
PVSTEPTPPP TRPPITPKQR VSCAGAKLDL VFVLDASTSV TEPNFELMKD FVKDFLLDAD
IDGGNVRVGV VIYSDADYVQ FQLNTYAKKA DVYNAIDDIP YRYGSTNTAD ALKTMRSVMF
TAGNGDRSDV DNVAVVVTDG VSNINSRRTV PEAEQARAEG IHIYAIGIGL TDTKELDGIA
SKPVDENRFA VQDFTELRDL RHKVFSALCS TLPPVRTKPT PPPTTPKQRV SCAGAKLDLV
FVLDASTSVT EPNFELMKDF VKDFLLDADI DGGNVRVGVV IYSDADYVQF QLNTYAKKAD
VYNAIDDIPY RYGSTNTADA LKTMRAVMFT AGNGDRSDVD NVAVVVTDGV SNINSRRTVP
EAEQARAEGI HIYAIGIGLT DTKELDGIAS KPVDENRFAV QDFTELRDLR HKVFSALCST
LPPTRTEPTP PPTRPPTTPK QRVSCAGAKL DLVFVLDAST SVTEPNFELM KDFVKDFLLD
ADIDGGNVRV GVVIYSDADY VQFQLNTYAK KADVYNAIDD IPYRYGSTNT ADALKTMRSV
MFTAGNGDRS DVDNVAVVVT DGVSNINSRR TVPEAEQARA DGIHIYAIGI GLTDTKELDG
IASKPVDENR FAVQDFTELR DLRHKVFSAL CSTLPPVRTE PTPPPTRPPT TPKQRVSCAG
AKLDLVFVLD ASTSVTEPNF ELMKDFVKDF LLDADIDGGN VRVGVVIYSD ADYVQFQLNT
YSKKADVYNA IDDIPYRYGS TNTADALKTM RAVMFTAGNG DRSDVDNVAV VVTDGVSNIN
SRRTVPEAEQ ARAEGIHIYA IGIGLTDTKE LDGIASKPVD ENRFAVQDFT ELRDLRHKVF
SALCSTLPPV RTEQTPPPTR PPTTPKQRVS CAGAKLDLVF VLDASTSVTE PNFELMKDFV
KDFLLDADID GDNVRVGVVI YSDADYVQFQ LNTYSKKADV YNAIDDIPYR YGSTNTADAL
KTMRSVMFTA GNGDRSDVDN VAVVVTDGVS NINSRRTVPE AEQARAEGIH IYAIGIGLTD
TKELDGIASK PVDENRFAVQ DFTELRDLRH KVFSALCSTL PAVRTEPTPP PTTPKQRVSC
AGAKLDLVFV LDASTSVTEP NFELMKDFVK DFLLDADIDG DNVRVGVVIY SDADYVQFQL
NSYAKKADVY NAIDDIPYRY GSTNTADALK TMRGVMFTAG NGDRSDVDNV AVVVTDGVSN
INSRRTVPEA EQARAEGIHI YAIGIGLTDT KELDGIASKP VDENRFAVQD FSELRDLRHK
VFSALCSTSP PVKNEPTPPP TTPKQRVSCA GSKLDLVFVL DASTSVTEPN FELMKDFVKD
FLLDADIDGD NVRVGVVIYS DADYVQFQLN TYSKKADVYN AIDDIPYRYG STNTADALKT
MRGVMFTAGN GDRSDVDNVA VVVTDGVSNI NSRRTVPEAE QARAEGIHIY AIGIGLTDTK
ELDGIASKPV DENRFAVQDF TELRDLRHKV FSALCGAIPT ASSECALARA DLVIVIDSST
SVTESNFDKI LSFVKDFLSK TDIDSGNVRV GLITYNNEVS QEFYLNSAFT KREILELVDD
VKYNFGSTNT AEALEIMRNV MFSPEKGDRA DVPNFAIVLT DGVSTVNAER TVPNARLAHD
DGIHIFTIGV GLSDTRELEG IATPPASQNS FKVDNFDALE YVDDLIFASA CYKNYTYTMP
PTTTTTRRTT TTTRRTTTTT TPTTTTPRTT TTTRRTTTTT TPRTTTTTTR RTTTTTTPRT
TTTRRTTTTR STTPRPTTTP KRTPKYKDQG TDIIFMMDSS VNNQLFGWMK SFLRDFTNIV
NVDDGEWRIG AMTFDRSTRN EFHLNRYPFN DEVVGALNRV NNRPSSSDPD VAGAFDYVRN
SMFTASNGDR PRARNYVIIL TGKEKSLNTE RSYAAANRLK DYGVDIFSIG FNFRNSTELD
EISSKPVEDF RYLVFSEDQL KEIPNTFLYN IRNAPPQTPR PQPATTPRPT RPPAPPYTGK
CDAKGDIIFI LDSSGSVGEE NFRMMKNFTY STVKDLSIDN GYFRVGIITF SDSSRIEFHL
NGYNTREDLI EQIEKIPYTY GYTHTAEALR RVRTEMFTQR NGDRSDAPNL LVIVTDGHSN
INHEETLPEA RRIKETGTTI VTVAVGVKGN YELRQMTSEP VDENLLEVTD FSALDQITRL
IVAPVCTDEN RCERNPCRNN GECVDGLRSY MCRCLPGFYG TNCEKACGPP ADVVLILDSS
TSVGPTTFED IKKYAQAMIS ELNIMTCNIQ VGVIKYSSAA MIQFNLGTIF TEEGMYRAIG
DISYTPGRSN MAEAFRVVRT QMFNNRNGDR PNARNIAYLL TDGTVEVNKD ITSNEVELSI
DAGIHIFPLA VAIQDRSEIE YIAQVQNIPF LIIEDEKNFM EQSDQFLRAV VDTDDSCNPN
PCRNNGQCVD EPFGFTCKCP EGFAGEICDK VCSSSVDVVF VVDASKYNTG PDFRTIKRFL
KSNVKNLAFK SGNIRIGIVE YGAHPRLRLE LIEGDNKRTI NSVISSLRRV DGDPNLEQAI
KLVSSNVLFR GGDRKEVPNY VVILAREIGG ENTVQAINEL KSKGTKFIGI GMGLSKSDEK
LLEIAVSSAL EDVHHLLDGP QRLEGIALDF ATLVCEAKDQ CVNSPCQNGG TCENGEKTYA
CRCPPGFAGK NCERACDDSA DIVFLIDSSG SVGFENFRHI KEYVQNVIDH FNIGPTATQV
GIATFSQSSK AEIFLNSYKD KRALKAAVSG LKYEYGNTNT ASGLKLSRTY MFSPAKGNRP
NVPDFLVVIT DGLSNVNPEF TIPEAELARK QGIHVIAVGI NLKDNDDWEL KGIASEPVNA
NVFRVNAFDK LFDITDKIVD NTCRDQSVCD TNPCKNDGNC IASAGSYTCQ CQQGYLGPNC
EYDCQNNKDI VFILDSSASV GPSNFELMLK YVSEVVKDLT LYGQDHRFSL VIYSTEVKTI
FSFNRYNSPK DILNAIKTTV YMPGSTNTAG GLRQALELFS SSFGDRPTAD NIAILLTDGQ
SNVNYLDTIP AATDLKAEKN KVITIGIALQ NLDEIKAIAS SPKDVFQATS FEQLKAVERN
LIEGTCSTD
//
