ID A0A2C9JWG0_BIOGL Unreviewed; 645 AA.
AC A0A2C9JWG0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
GN Name=106070697 {ECO:0000313|EnsemblMetazoa:BGLB009084-PC};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB009084-PC, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB009084-PC}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB009084-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_013086109.1; XM_013230655.1.
DR AlphaFoldDB; A0A2C9JWG0; -.
DR EnsemblMetazoa; BGLB009084-RC; BGLB009084-PC; BGLB009084.
DR VEuPathDB; VectorBase:BGLB009084; -.
DR OrthoDB; 1114672at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF473; FI21270P1-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 317..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 315..554
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 572..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 645 AA; 71716 MW; D0F1B4C8F4C09684 CRC64;
MRCNTSSVED CLATVINMTS DSRKRNQNVM TSFYELLDDL SEMIGKGAVT QLVDDIQLYA
RILDVNLGFC QPYESSCTEK RKSDLLEKAE LFTDNVVLSE DSDPDFKEFS FTLDQLDMFM
VKSVYGAIRG RTLQMKSGVI TIEDIAPSQQ VNNSARIFVS AMIMHLPRSN VQFIHQSQDD
LFDAALVSPV LTLKAYMEKS KVNVIHNFSL LAKSYENDSN IPVCAFQRTN ESNNPDGDVW
DTKGCMVVED QGPPAGFAAL GPLIDRSGGP QGHRHNLSAL RQERVIGCHC NHTTNFAILM
QTVEFQVKDT DALALSIITY IGCSVTLITQ IMAITVFTCI RSLNSERVCV HRNLCITIMM
AQVTFIAGVT AVDDKVVCAV VAVALHYLYT ATFVWMLVEG LHLYSQVVRV FGTEKSRILY
YIFFGWGVPL VLVAISAAVD WDGYGNNRSC WLSIQRATIW AFVGPAIAII LVNLVILILV
LRIVITSSKV DKQDSMKNVR AGIKASLFLA PLLGLTWIFG LASVSEQLVA FQYIFAILNS
LQGFFIFLFH CALNTEVRQA LARLRERRSL QKGDFGSSTS NSRPSSSDSR SSSGGGITVS
ERWTSMTKSR NRIEPSISNK ETLPDILSQD ETFKSQGLNW KTNLL
//
