ID A0A2C9JYV5_BIOGL Unreviewed; 716 AA.
AC A0A2C9JYV5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Translation initiation factor IF-2, mitochondrial {ECO:0000256|ARBA:ARBA00044200};
GN Name=106073379 {ECO:0000313|EnsemblMetazoa:BGLB010224-PC};
GN Synonyms=LOC106073379 {ECO:0000313|RefSeq:XP_013089366.1,
GN ECO:0000313|RefSeq:XP_013089367.1, ECO:0000313|RefSeq:XP_055880133.1,
GN ECO:0000313|RefSeq:XP_055880134.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB010224-PC, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB010224-PC}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB010224-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_013089366.1, ECO:0000313|RefSeq:XP_013089367.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000256|ARBA:ARBA00025162}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
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DR RefSeq; XP_013089366.1; XM_013233912.2.
DR RefSeq; XP_013089367.1; XM_013233913.2.
DR RefSeq; XP_055880133.1; XM_056024158.1.
DR RefSeq; XP_055880134.1; XM_056024159.1.
DR STRING; 6526.A0A2C9JYV5; -.
DR EnsemblMetazoa; BGLB010224-RB; BGLB010224-PB; BGLB010224.
DR EnsemblMetazoa; BGLB010224-RC; BGLB010224-PC; BGLB010224.
DR GeneID; 106073379; -.
DR KEGG; bgt:106073379; -.
DR VEuPathDB; VectorBase:BGLB010224; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR Proteomes; UP001165740; Chromosome 3.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR CDD; cd03702; IF2_mtIF2_II; 1.
DR CDD; cd03692; mtIF2_IVc; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR HAMAP; MF_00100_B; IF_2_B; 1.
DR InterPro; IPR044145; IF2_II.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR000178; TF_IF2_bacterial-like.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF20; TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|RefSeq:XP_013089366.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP001165740}.
FT DOMAIN 175..345
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 716 AA; 80148 MW; 2DBC2764BC919DF5 CRC64;
MATWCLLGGL LKRIKYGKIS NDVFSAINRL QTSEHKLFLR KLNIWSFYIN SARMLYTSNV
YLGHKSPKGK ISKKDPLKTN KSIKLGRAYI HEQMTIAEVA RALNKPIDHV YEVLMLIPDT
ESYDHDDSVL PRDILVSVVK KSGMIPEFIS NKVEKEEESG DFVKQAPPDP SVLVKRPPVV
TIMGHVDHGK TTLLDKLRNS NIVDQEFGGI TQHIGAFKVI MPSGESICFL DTPGHAAFSA
MRERGAHLTD IVVLVVAADD GVMQQTLESI HYAQDAGVPI IVAINKIDKN NADVARTKQM
LLEHEIQLEE FGGDVQVVPI SALKGTNLME LQEAIVTQAE LMNLKGDPVG LVEGRVVEAR
IDEKRGRLVT AVIQRGTLKR GDYLIAGTAW GKVRAMFDEF GDPVQAAPPS TPVEILGFRE
IPSAGDELLQ VKTESELKSV IAWRQEQEKK RKQIEDYTVI AEKREEHLKD YRTALQARRE
KGIHKERRKG PRPKEIVTDI DDVHYSMVLK GDVDGSVEAI LDTLDTYHSK KCHLDIIHYG
VGAVTESDVE MAAIFNGDLF AFNVMVPVKV AELAKSKKVV IKKHNIIYRL FDDLISSINK
KLPKIEEHVV TGEAKVLQVF QVTLPNKTKA NIAGCRCTNG VISKKLGIKV LRNDEIVYTG
KMVSLKHFKE EVDSIKKEQE CGIGIDDPKF AFEPQDVITT YEIKLVDQEV DWQPGF
//
