ID A0A2C9K0H9_BIOGL Unreviewed; 835 AA.
AC A0A2C9K0H9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:BGLB011062-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB011062-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB011062-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB011062-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A2C9K0H9; -.
DR STRING; 6526.A0A2C9K0H9; -.
DR EnsemblMetazoa; BGLB011062-RB; BGLB011062-PB; BGLB011062.
DR VEuPathDB; VectorBase:BGLB011062; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 4.10.470.20; -; 2.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF29; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; 1.
DR Pfam; PF00008; EGF; 10.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF00066; Notch; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00004; NL; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 14.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 13.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 15.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50258; LNR; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..835
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012406467"
FT DOMAIN 30..65
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 67..104
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 145..179
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 182..218
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 220..252
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 255..294
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 297..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..372
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 374..411
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 413..449
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 451..487
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 491..529
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 530..566
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 568..604
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 607..643
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 642..692
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 735..772
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DISULFID 55..64
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 94..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 149..159
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 208..217
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 224..234
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 284..293
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 323..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 339..349
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 362..371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 401..410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 439..448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 477..486
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 500..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 519..528
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 556..565
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 594..603
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 633..642
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 835 AA; 93251 MW; F7C437104B7BBA79 CRC64;
MINRSGLTMM KVVLISLATF TLCVSPSYCQ DACMSQPCQN NGECKPMEGT FECRCPKGIT
GNLCDIDIDE CASNPCRNGG RCTQTTVNNY TCNCPLSFTG QNCDTYIDHC MPNPCRYSKC
INLEKGYRCD CFFDFVHFNE THCLPTNNCS TNICRNGKCI QDTKSYKPSC QCFGGYFGEF
CDKEKCSSNP CQNGGTCQNF KNNYTCHCAV GYSGPLCETV IDHCASKPCI HGQCFNSHDR
YDCKCDTNYT GDNCERNVCD PNPCNNSARC IPYENSYRQY MCICSPEYYG VNCEKPQRNY
CDYKPCGDRG NCTGNLTSYE CHCNKGFQGK QCEEKRNYCH PNPCNNGTCA NLSNGRGYKC
MCFEGFTGST CQQDVNECSA LNPCSNNAVC INDIGGFHCQ CPQGFSGTLC DQRDIHCFEN
TCINNGSCFD QFNGYTCKCP KFYTGSNCHY KIEPCDKKPC MNGGTCFYTG DGFKCKCPPG
FTGPRCECKT TDQLCRPNNC DIIGTQIYQP VVDGYKCICT SHWSGQYCNT SVDCDTITCH
NGGTCEDSQY GAACICPVGY FGEHCENQMS KCYPNPCLNQ GTCTEKNNNY MCSCPDWATG
ENCKTQVYLS CDTSPCLNGG SCVLRDGSYV CDCPKYWTGY KCQDPLRLVS QICLDNKCME
KGNNGVCDQE CNYEECLYDN TECSFGMIPW QNCTQRTAKG KSCSQAFDDG ICNQECYTAN
CLFDGYDCDP PAEECRYKNY CETYYSNSQC DSGCNNAACG WDGLDCEQDQ QDVFEGSIFI
IIAKRPEDFE KMKTEFLYMI SHLVQAAVRI RKHSKDEMAN VINSSSLTMR DGMTV
//
