ID A0A2C9K2C2_BIOGL Unreviewed; 2418 AA.
AC A0A2C9K2C2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Laminin G domain-containing protein {ECO:0000259|PROSITE:PS50025};
GN Name=106078658 {ECO:0000313|EnsemblMetazoa:BGLB011984-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB011984-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB011984-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB011984-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR RefSeq; XP_013095064.1; XM_013239610.1.
DR STRING; 6526.A0A2C9K2C2; -.
DR EnsemblMetazoa; BGLB011984-RB; BGLB011984-PB; BGLB011984.
DR GeneID; 106078658; -.
DR KEGG; bgt:106078658; -.
DR VEuPathDB; VectorBase:BGLB011984; -.
DR OrthoDB; 4072625at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR45739:SF11; C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 11.
DR Pfam; PF02210; Laminin_G_2; 2.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS51854; CSPG; 8.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2418
FT /note="Laminin G domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012813036"
FT TRANSMEM 2229..2252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..195
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 205..386
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REPEAT 668..765
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 911..1005
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1144..1233
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1255..1348
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1365..1458
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1482..1572
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1712..1809
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1840..1931
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REGION 2175..2212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2356..2386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2198..2212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2363..2378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2418 AA; 271020 MW; B2E82D95B4F07747 CRC64;
MAEPWSLLIL TFLCSFTLTS CKLTNEVSFF GESFLLNPLR ETSSSSWIKL DFYTHMSQGL
LFLAAGGTDY ILIQLSGGTL EVRVNLGHGE AVAHSARGVS LNNFQWHSVA LNRTKDKVYL
VVDGSDQVEM VVPGLDHNLD INLGVYVGGT GLLRTDLGSY SKSFRGCMRE VYYNGQNILQ
NMKSLKNSNN IVWHCADEFK VTSLRPISFN HYSSYVAFPH FRMDSNHQGL ISFEFKTRSK
NSVFLFNSGV GKTFQNFIAV ELIDGKPKLS LRLDSDTVEV VTQLVANDGR WHHLEVLLSQ
TLVQLSIDGN KNTSPLSIHS NINLGGHLFI GGLGPKSQQH ALQLGLMSHE DNTKKSMLGC
VRNLQVNSFN YNYHHIQISR QISTDCAWDF PCASDPCVLN AQCTELSGSD FKCDCGEDIC
VRKEFQLDAN LKLENLVGFI TAGNLMVKEK TSALVGTNVI KINKDVLRSS VREESIVFFV
KERPSEGFID IKGKSHQDTF TIKDLNENTV YYRHLGGKVK QDSITFQVSF TVLTKEPGST
SEHFNFVLPV TIVSSPNLEV SLKSGQILNI TSGAILRITP SILNVKSSGI DPTLLRFSVV
FLRPSPSSFE SSEAQKKQIL SFLLKDVQDG KIWFRHKDDS IVYTKVNVTD GVSISNAVDL
RFKVEELKLI VRNNTGININ YGAHYLMTAN NLSTTTNVPL EELEVRYNIT KPPTQGSIQR
LEYSTSQWSN VTTFTQRHID AGRIRYLHLP GKSIAMLDNF TFEVVAKHQK TEPQVFRITF
KPVTLTIEQN YNLILYNVPY GKLTNRTLLV VSGSPDFKAN NMEYTLVRAP QFGTLYLIKQ
HVSTNIPFEE YQSLQLEGSF TQQDINSGFV YYKIDKPTFE RKTDYADLHA SYFGFNIMVR
AMFEFSPKQL TARLINNGLK DVPEGGSATI TGNDLSLEID SYKQFKFWVI TGPKHGSINI
QDPASSTISQ HNVTSFTMSD ILNGRVIYSH DDSENGADSF TFLVNPQIED SDLDAAGEFQ
ELSGTFKIIM KMNNDNSPIR SVNKVFHIAT DQTKLLSIDD LAFRDPDIDF DDSKLAYQLQ
PIPNGEIINV MSKELVLNFT QSDLKEGKLV FKHKGETYAR IPISVSDGKF FTSSLFVVQA
SPPYIKVVNN TGVEVKQGAS AAISSFNLSL ETNLNLNPET IIFRVVEAPK YGIIRIDGRN
TNDFKYQDLI KAKVRYWHNG GNSREDKVIF TVQLESLRIQ VPFSLKITAD GVSDPPEIIH
NQILKVTAMQ SETITENHLN VAHKNYPPHE IEFIITQLPR SGHLVIKGNP VKTGSAPEFS
QQDIIEGQVV YVSDTSDALS DKLVFDVGTE FQSLRQLDFL IEIVPQTLQM NRVNAKVREG
GTLVLGSSLL LFKPQLPISS KAALSLYQIP VHGKVMLRNG QTENQVNAFT YEDVSRGRLV
YVHDNSESLS DELAIRLEHQ EGKLPGRMIV VLIEVTPVDD QPPFVVTNAG LDLWTGSLQL
LTNKQLMATD PDTSSDHIEF RVSAPSNGHI AYLNNTFKQI TKFTQRDLDS GSIVFVHKGS
ETGTFTFQAT DGINADQSRV FRVRARPVEL SVITNNTIRV FPGFTQPITN VSILVKTSSS
NFTHPILFSL LDTWPRKGKL VTIVNQKPVE ISTFTQSDIN EGKIFYKHTA ETKSWIDTDV
IYFEISTAYA QALVSKALKV EISFSHINQD NYRQLLHIKP LNIIEGGKIT INKDYLDSTE
FIAKIRAFLP VVDVEFSFAV PPRQGYLWFD GQQAAVNQKF TQEDLNKGDL TYKHDNTETV
KDRFKFAVKL IVPKAYGGYT NSEQIFTMDI FIEPVNDRGF ELITIHPRIT VKQGSQVVIT
PSNLTTIDMD TGPEEIKYTI VTQPSNGMVV KLPDNRTRIS SFSQKDINDE NIMFRHDGTR
KSSDSLYFKV WDGLFDPHFS NMNILVILLN INVAKDSFVP LIQGNKSVTV TSKHLKVSTN
GDYNSLIYKI IQRPQFGRLM KLNTPAVEFS QGDLDKGYIF YNQNADSPGD DYFTCSIRLK
NMDSFHDEIG FDVTMMPLLK QNPLVTSAGS FVAITRSTLD ASELAHMTND NPRFTISKYP
KYGKIMRRHR QRREANLENH FQSVTSFTFE DVVYTQIYYV PNDDTNHNGS DSLVFVLSAR
GVPSAKGELK IQLNEPTIVP NRPTHTDVEK TTPIDDSHQE SQGDSGSKNV SQEAVVESGV
SLDDDNNGVV IGTVLSLILI ICVAVVLIVL YLRWRRRNQP MSLHQAKAAK PRPYISGPLQ
LEQPNVHIEP HDGGLSSPMS RESTALMSGS HGAESEYMNT TDMANSGETD SLHQLTKDSD
GSLNIMKVDV SYTMPGRRTA LGKDTESASE ELDRPSTRAS GRESNASTDL MDWSLMEPDL
LQHCRTTTPI LSYNQYWL
//
