ID A0A2C9K3N9_BIOGL Unreviewed; 947 AA.
AC A0A2C9K3N9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 1 isoform X2 {ECO:0000313|RefSeq:XP_013096753.1};
GN Name=106080019 {ECO:0000313|EnsemblMetazoa:BGLB012573-PC};
GN Synonyms=LOC106080019 {ECO:0000313|RefSeq:XP_013096753.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB012573-PC, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB012573-PC}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB012573-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_013096753.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013096753.1; XM_013241299.2.
DR AlphaFoldDB; A0A2C9K3N9; -.
DR EnsemblMetazoa; BGLB012573-RC; BGLB012573-PC; BGLB012573.
DR GeneID; 106080019; -.
DR VEuPathDB; VectorBase:BGLB012573; -.
DR OrthoDB; 5477406at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR Proteomes; UP001165740; Chromosome 10.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046:SF5; EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF12661; hEGF; 1.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP001165740};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..947
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041060886"
FT DOMAIN 74..114
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 235..275
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 276..314
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 760..872
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 280..290
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 947 AA; 106414 MW; 25F0FE3BC57D1B07 CRC64;
MKLTTGCLLR LFLTLMVIAL VCEGKSPSTT NKDDDECHDE NGGCAQNCIN TPGNYTCACH
DGFILAPDGK DCIDKNECFE NKGGCSHQCV NSLGSFECKC NSGYSLISSG KQCEFGEWCR
IMHGCDHNCR TSSTSNKVEC FCRTGYFLHS DGKRCVRSCE LGNGGCQHKC NTTADGPVCS
CAARYLLNLD GKTCRASCSV NNGGCERKCM DSINGPVCQC PEGFKLHQDG RSCIDVDECE
KKMDGCSHMC ENIKGSFECV CPPGYKVSSD YKTCVDIDEC VMKSTCDHKC ENLPGSFKCH
CKPGYQLYGV THCADINECS VQNGGCVYNC TNTEGSYKCS CKEGLKLHPN KHDCIDMRQC
TTVVQQPNSV LTCVPVGPKE QHCVMTCEEN AFLINDAGYL NSTSISFRCG PSTNYEWTNM
PTGKLPQCSR NILAPSLTKK ARFVLIRDSC SVEPVEAEMI KKNLTDIFNY DQKYKCNNSC
QINFVEFSCG SRRKKFQQMA KRSGKKLVTT EFELQINPRE ISYNCDVDCR SKKTRKKFNK
ILKKARQSIK GQKFSIRLYN KEYKPMKKSF KPEKAVEELC VNGTQLINKT CIGCSYGTYY
DIQTKKCTLC PWGTYQDKEA QFSCIECPNW QPGSGQEGAT TLEQCNDLCE PGTYSTSGRK
PCLLCSVGTY QPKYGRISCR PCGMGLRTKS TGSTGFQDCL VKVTCKAGHY YNISTQTCSS
CPRGFYQPRT GQDFCYTCPG KTMTDFEGST LAEDCKDRRC GQHMGDYYGI LESPNYPGNY
PVNVECVWKI KPQKQRRILI IIPQIQLADN DKCEDKIIMR KTKNPYSQNS YETCESRERP
IAFTAKSKKL WIQFKSTGNK TAQGFSIPFV AYNEEYESLV EDIVRDSRLY STSQHQQIFK
DRQLLTVLLE VIATPYSYLK YFNVSQSMFP PSFINLLKPK VRRFFQS
//
