ID A0A2C9K3S2_BIOGL Unreviewed; 741 AA.
AC A0A2C9K3S2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Cubilin {ECO:0008006|Google:ProtNLM};
GN Name=106080185 {ECO:0000313|EnsemblMetazoa:BGLB012634-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB012634-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB012634-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB012634-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_013096964.1; XM_013241510.1.
DR AlphaFoldDB; A0A2C9K3S2; -.
DR EnsemblMetazoa; BGLB012634-RB; BGLB012634-PB; BGLB012634.
DR KEGG; bgt:106080185; -.
DR VEuPathDB; VectorBase:BGLB012634; -.
DR OrthoDB; 25854at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 3.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF37; CUB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 3.
DR Pfam; PF07645; EGF_CA; 4.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..64
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 111..152
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 240..284
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 286..397
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 444..485
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 538..575
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 577..620
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 624..741
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 565..574
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 624..651
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 741 AA; 83993 MW; 6832A7E85B2347F1 CRC64;
MDYVTFFDGP SQQYPRIGEI YCGYNNEEST LGILIRSTGN TLTVVFKSDS LGSRTGFSAS
YRAIDCEPFT YGYETCNQNC SCIKANTDYC NNIDGRCMCN ANWTGWDCSA LIDRCQDPNI
CSDLYATCVN IPGGYECRCK PGLAKNSTGH CAELKKCTQK QCSHYCGLTE TNPQTETCHC
PKGMKLGNDT ITCVECSDWY YGDDCAHYTQ CYPSRTESYN KTNGLCHCFL NWQSTYCEED
FNECTFIKQP CVLEKDHAQC YNTYGSFECR CSPGFEPINE TTCDECGKVF TATSGTINST
SHLVDRNVSQ DCNWTISAPV GHVISLRFLA MNLCYWCCSY VYIYNGNHTN SVIWSGSYWP
SSNLVRSSGN EMLIVQYPDW CDNRRDFIGF TASFWTHECP PNMYDDNCST PCSCDVNNTI
GGCNSITGYC PCKSGWTGSD CSVDIDECSQ NYFLCPDYSR CHNLPGSHEC RCKPGLVMGS
NNVCIYDINS TNCTTRNCSH MCVSYTPVNK TSPVDQCYCP IGKELAGDQC IDCTDWKYGP
DCELSTSCFR NHTAKYNSYN GQCSCYPNWT NTYCEDDYDE CYYGTYTCQP HALCSNTYGG
YVCYCNERYG YIEVTNSTCE HIDCKKTFTN ETGAIINYFY NRWFVIQNSN CSWLISVRSD
YVISLRFSTF YIESSYGCQN QYFEIYDGNS VSSRRIGRYC GSGIPSVIRT TGNNMLVRYV
SDSSYYNYYY YGNFYATYTS H
//
