ID A0A2C9K4F2_BIOGL Unreviewed; 889 AA.
AC A0A2C9K4F2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=FH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=106050830 {ECO:0000313|EnsemblMetazoa:BGLB013004-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB013004-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB013004-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB013004-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR RefSeq; XP_013061333.1; XM_013205879.1.
DR AlphaFoldDB; A0A2C9K4F2; -.
DR STRING; 6526.A0A2C9K4F2; -.
DR EnsemblMetazoa; BGLB013004-RB; BGLB013004-PB; BGLB013004.
DR KEGG; bgt:106050830; -.
DR VEuPathDB; VectorBase:BGLB013004; -.
DR OrthoDB; 623207at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR InterPro; IPR027649; Inf2.
DR PANTHER; PTHR46345:SF8; FORMIN 3, ISOFORM B; 1.
DR PANTHER; PTHR46345; INVERTED FORMIN-2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 1..310
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 502..889
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 403..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 772..806
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 403..487
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 99559 MW; 31BBFF11DABE56CE CRC64;
VRLLLIFVGY SNALDYCLFL LAIPTVHTFS SVKKKLRNSK QEWLQGFLDH EGLERLLDCV
DTFASKRVTA LSDALILVEC VECIKSVLNS KIGLSVLVHK SEYTRRLIKA MDTSNAMVKK
QVIELLAALC MYSVDGYKLA MDALDTFKTM KQMRYRFSLV INELKSSELT AYKTSLMAFI
NCILCACEEL YERNRIRNEF IGLNLLDIIP DLRNLTDKEL DIQCDVFEDF KYDDDEELAV
CFSESVDVTN HRQLFEIIFN KVYNTPLADK FLTILQTLLQ IDLDTNLSDV QWDLMEHAAQ
TVVTIDTDKA DKYVDLSNVV KILLNRLKTS FNIPVHGSSD TKVDTKHSFV QTDLDPASFM
NNVVSSGEAE ASTSQANCTT SLSSLSVISE PFLHQSLPCL TNAPSPPHPP GFVGEAAPPP
PPPPPGFVGE AAPPPPPPPP PPPGFVGEAA PPPPPPPPPF GVVGGPPPAP PPPGGPIPPP
PPHGLVGNLP PLKISSNSSY RPIATPKPKS KMKTFNWSKI PEQSLNKEDS VWKEVLAMED
KVEVHYDQIE QLFCQKIAET KPEEPVKVKT PTQVNLLDMK RSMNANIFLK QFSKMSHEEI
VNLIKEGDPS KIGAERLRGL QKILPDNDEV AMINNYKGDV NQLGNAERFY LLLSKLSGFK
IRVEGMLLKD DFQGAMESLL PNVDCLIVAC DNLMDNKSLK SFLRYVLHAG NFINAGGYAG
NALGFKMSSL NKLSDTRANK PRVTLLHYLV EEAEKEQEEI LQFADQLLPS LKEASRLTVD
NLNSELKLLE KNVKKLEIQV SQSDGDIKDY FDQFIKEANI KVNLVQGKLV QIQELTLKLS
HHFCEPEKGF KLEECLNNFY TFCQKVKQCE KDNEQRKVQE ERAEKETRK
//
