ID A0A2C9K4I5_BIOGL Unreviewed; 1308 AA.
AC A0A2C9K4I5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=DENN domain-containing protein 5B-like isoform X4 {ECO:0000313|RefSeq:XP_013061459.1};
GN Name=106050927 {ECO:0000313|EnsemblMetazoa:BGLB013053-PD};
GN Synonyms=LOC106050927 {ECO:0000313|RefSeq:XP_013061459.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB013053-PD, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB013053-PD}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB013053-PD};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_013061459.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013061459.1; XM_013206005.2.
DR EnsemblMetazoa; BGLB013053-RD; BGLB013053-PD; BGLB013053.
DR GeneID; 106050927; -.
DR VEuPathDB; VectorBase:BGLB013053; -.
DR OrthoDB; 5398783at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR Proteomes; UP001165740; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17677; RUN1_DENND5; 1.
DR CDD; cd17678; RUN2_DENND5; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR PANTHER; PTHR46070:SF1; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP001165740};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 28..575
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 769..971
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 975..1083
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1150..1301
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 393..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1100..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1308 AA; 149541 MW; 87D28B9EE409CF5A CRC64;
MAVQDKPFRF VDYFVICGLD ENADLEPDKL SGDTQQSPPL ERPYKSRVLA HFPENVTWNP
FDENAVGMLC LPRGLSFKTQ WDSRQPKFHS FVITRENGSK AYGSALIFYE EVMAKSVLDT
MQTLHAMHQA NVAVKFSLDS PEPVRRIMSE RKSKQCPFDA VRDKLFVSKC ICLVTPMPFV
RSCQQFLYQL YEASQKPSQL TMTLESYVFN IIYDVPLPPS GRSMQFFSCA SPIYVIRPST
DDLPLLDFSL YDMFKLLGID GVVDIFKCVL LEHQILLYSS DYQRLMLVAE GMTSLIFPFQ
WQLVYVPILP ASMQHFLDAP VPFIMGLYKV SNTDKSQLVL PSEANMCFVE IDNKNIDFPE
DLPMFPYQNE LKIELTQVIN KYQNIIGAET MSRSYPTTPR RETGYKSSSG LRPDDTSNTN
TGSWPNSPKR KEILQNSEAW KKISSIAKKT GVWDSIEDIV LEDSAPGDND REKDSIDGGS
GMPSCEVNTL KFNNAVREIV LNCFVHMFSS YENFVINPSQ DLESWLSNRE TIHNFDKAAF
LSDQPASHLP FLSAFIETQM FTTLMDNKIV SQWEETDPGL QLFDARIKNL KDAAGGEPRI
ITYSPCSTME RTEQSLEKKA KNINFIACKP HEIASHISPS QYVGGVFPLL SKELLNSEPA
NSKSKFRENA KWRRKDRQLQ HKEHLQTNVE ADQQEFPVEE KKISLWVQYL RIRKPQLPDM
SQAGTAQTNW KFVETLLKEC KTKTKKMLVD KMGQEAVELG HGEASIIGVE ENTLIASLCD
LLERIWSHGL QAKKGKSAVW SHLLSYQETE ESSDNKPVDP KLLTPGFLPK DQNNYWENRK
EIDLSNIGMD PDKVQQERGS EKTHRRRGSQ GRIELPVLRP MPKSLLIDMK KIQQMSDIHT
DVGKTRALIR LALERKMLSA HLKQLLSNTD LLRNLYKRYA FLRCEDEREQ FLYHLLSLNA
VDFFCFTNIF PNSVVPYRIL VYPSTKLGCS TTSANVWISL AGQMGETGSM ELPKSLLEMN
FEHKNLGILT TLRIGHDNSG MMPRWLVEYV LVRNELTGHT YRFNCGRWLG RGIDDGSTER
LLVAELMHHT IDTEDEVVVT SPPRTCSPKS PRKSHDANSG LADIQENLGQ AVNNLVKHFY
KPEKERGNIT YLLCGDKGLV HCMEQVFQFG FRSSRLFRNK IFIWDYMERL KTFFESALSG
NTSHQLNEVT KAGYWLFCDL VGKINTASDT VGKDGKFQVF ICVGIRKRCL HRWLPLMADT
TVTAQMYEEN SFLRNQAHIN FVMHILDSLT EFDIPLETSL LRGIDLGM
//
