GenomeNet

Database: UniProt
Entry: A0A2C9K608_BIOGL
LinkDB: A0A2C9K608_BIOGL
Original site: A0A2C9K608_BIOGL 
ID   A0A2C9K608_BIOGL        Unreviewed;      3366 AA.
AC   A0A2C9K608;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   11-DEC-2019, entry version 15.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:BGLB013796-PB};
GN   Name=106052673 {ECO:0000313|VectorBase:BGLB013796-PB};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda; Heterobranchia;
OC   Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea; Planorbidae;
OC   Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|Proteomes:UP000076420, ECO:0000313|VectorBase:BGLB013796-PB};
RN   [1] {ECO:0000313|Proteomes:UP000076420, ECO:0000313|VectorBase:BGLB013796-PB}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BB02 {ECO:0000313|Proteomes:UP000076420,
RC   ECO:0000313|VectorBase:BGLB013796-PB};
RX   PubMed=15562597; DOI=10.1645/GE-284R;
RA   DeJong R.J., Emery A.M., Adema C.M.;
RT   "The mitochondrial genome of Biomphalaria glabrata (Gastropoda:
RT   Basommatophora), intermediate host of Schistosoma mansoni.";
RL   J. Parasitol. 90:991-997(2004).
RN   [2] {ECO:0000313|Proteomes:UP000076420, ECO:0000313|VectorBase:BGLB013796-PB}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BB02 {ECO:0000313|Proteomes:UP000076420,
RC   ECO:0000313|VectorBase:BGLB013796-PB};
RA   Warren W., Wilson R.K., Hillier L.W., Minx P.;
RT   "Sequence assembly of the Biomphalaria glabrata genome version 4.3.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:BGLB013796-PB}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|VectorBase:BGLB013796-PB};
RG   VectorBase;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   RefSeq; XP_013063554.1; XM_013208100.1.
DR   GeneID; 106052673; -.
DR   VectorBase; BGLB013796-RB; BGLB013796-PB; BGLB013796.
DR   OrthoDB; 414294at2759; -.
DR   Proteomes; UP000076420; Genome assembly.
DR   CDD; cd00112; LDLa; 24.
DR   Gene3D; 2.60.40.10; -; 8.
DR   Gene3D; 4.10.400.10; -; 23.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR000034; Laminin_IV.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR000082; SEA_dom.
DR   InterPro; IPR036364; SEA_dom_sf.
DR   Pfam; PF07679; I-set; 4.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF00052; Laminin_B; 3.
DR   Pfam; PF00053; Laminin_EGF; 9.
DR   Pfam; PF00057; Ldl_recept_a; 24.
DR   Pfam; PF01390; SEA; 1.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00181; EGF; 7.
DR   SMART; SM00180; EGF_Lam; 8.
DR   SMART; SM00409; IG; 8.
DR   SMART; SM00408; IGc2; 8.
DR   SMART; SM00281; LamB; 3.
DR   SMART; SM00192; LDLa; 24.
DR   SUPFAM; SSF48726; SSF48726; 8.
DR   SUPFAM; SSF57424; SSF57424; 24.
DR   SUPFAM; SSF82671; SSF82671; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01248; EGF_LAM_1; 5.
DR   PROSITE; PS50027; EGF_LAM_2; 7.
DR   PROSITE; PS50835; IG_LIKE; 8.
DR   PROSITE; PS51115; LAMININ_IVA; 3.
DR   PROSITE; PS01209; LDLRA_1; 7.
DR   PROSITE; PS50068; LDLRA_2; 24.
DR   PROSITE; PS50024; SEA; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124,
KW   ECO:0000256|SAAS:SAAS00895822};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00290237};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00580772};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076420};
KW   Repeat {ECO:0000256|SAAS:SAAS00580781}.
FT   DOMAIN          44..155
FT                   /note="SEA"
FT                   /evidence="ECO:0000259|PROSITE:PS50024"
FT   DOMAIN          597..678
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          1371..1456
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          1599..1690
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          1739..1929
FT                   /note="Laminin IV type A"
FT                   /evidence="ECO:0000259|PROSITE:PS51115"
FT   DOMAIN          1963..2054
FT                   /note="Laminin EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50027"
FT   DOMAIN          2060..2108
FT                   /note="Laminin EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50027"
FT   DOMAIN          2134..2313
FT                   /note="Laminin IV type A"
FT                   /evidence="ECO:0000259|PROSITE:PS51115"
FT   DOMAIN          2347..2396
FT                   /note="Laminin EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50027"
FT   DOMAIN          2397..2454
FT                   /note="Laminin EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50027"
FT   DOMAIN          2459..2510
FT                   /note="Laminin EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50027"
FT   DOMAIN          2537..2716
FT                   /note="Laminin IV type A"
FT                   /evidence="ECO:0000259|PROSITE:PS51115"
FT   DOMAIN          2751..2800
FT                   /note="Laminin EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50027"
FT   DOMAIN          2801..2859
FT                   /note="Laminin EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50027"
FT   DOMAIN          2844..2949
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          2953..3043
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          3051..3135
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          3182..3269
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          3276..3364
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3177..3196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          72..92
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   DISULFID        180..195
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        393..408
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        433..445
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        440..458
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        568..583
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        708..723
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        777..789
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        784..802
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        796..811
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        814..826
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        821..839
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        871..886
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        889..901
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        896..914
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        908..923
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        933..951
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        945..960
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        970..988
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        982..997
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1007..1025
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1019..1034
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1044..1062
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1056..1071
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1081..1099
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1093..1108
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1110..1122
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1117..1135
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1129..1144
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1146..1158
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1153..1171
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1165..1180
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1183..1195
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1190..1208
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1202..1217
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1222..1234
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1229..1247
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1241..1256
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1266..1284
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1278..1293
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1298..1310
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1305..1323
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1317..1332
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1352..1367
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1518..1530
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1525..1543
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1537..1552
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1581..1596
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        2025..2034
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        2060..2077
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        2079..2088
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        2366..2375
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        2425..2434
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        2481..2490
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        2770..2779
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT   DISULFID        2830..2839
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ   SEQUENCE   3366 AA;  374543 MW;  D1A1BA21080044DF CRC64;
     MLGDPTSTPL NSEDGSGTSE SPVEKVTAVT QTATIKVPVA VLPVVVDYPR YYRVTIHYSS
     LRYSPALEER NSREFRELAR ELQRDLENLF RNLLGLHTIT ILQVSRGLLV TFDLGSVGEA
     TEDEIRDTLL DSVRGGRIGN QTVSGQGFTF SKISVPAHPC TTREFFCSAN KVCINRTLAC
     DRRKHCPDGA DEQNCSEVSC PSHVGRNPDK LPRSGNNWAN LLVNNVFPCD GNIVGWEYYR
     LKPQGSAYVG VWRQDLFDSH FNLISKTELP SAPVGIREVS TNPISVKKGD FIGIFYPRTT
     PNNVIAQAQL ADDILSSNEL YQNFHIEIFD DDITQNNNLI NLENIDYNTI NATFSLRAVM
     DYEVGPTIPV IGLTCKPNEF NCGDDCISQD LYCDGQIDCN NESDEKDCAP QPATCPRGLF
     LCDDGTCQRT CDCLEGRFRC NDGTCIERVL KCNGQVNCPD GSDEGKVCQE TTERQCSDEE
     FQCYTGTPIC IPRDEECNGI PECEDKSDEL PDRCSPTFPT VLPACPPDYV RCQDGTCRKE
     TCDETEPMAC TDEQFKCNGE CFSLKMKCDG FKDCDDGSDE ENCGEIFITG PEEAIVGTQV
     KLTCNITGRL ERSNNIYWYK DDTINISSYS GNILNRIQIR HHDRREYHLS ELYLRQAEIS
     DSGSYTCATS QHVSRGFNLA VVLQVFTCEA NQFKCKREER CIDERRRCDG RHDCRDKSDE
     MECCMYLANL FLPAKKNNLS SMSKFIMYFH VFFYARHVTT NVLFHSVCLA AYAAVACRVD
     QFRCASGGCI DQGRRCNGQL DCSDRSDETG CKRCQETDFT CTSGQCIPFE QLCNGERDCE
     DGSDELCEFK CAENQFICNV EKKCINLDYT CDGNDDCLDG SDEQSCPGCK KNQFTCSDGS
     CVRNTSRCNR IRECRDYSDE FKCECDEVLE FSCANGQCVP ASARCNNNGD CYDRSDEENC
     GCDAETELTC GDGSCVPLSA RCDRRYDCSD RSDELECGCD PQTELTCGDG KCVPLSARCD
     RRYDCSDRSD ESDCRCNEAT EFTCDNGQCV PLRARCNRRF ECSDQSDETN CDCDPLTQFK
     CADGQCVASS ARCNRRFECR DRSDEENCGC SRTEFTCDDG SCVDRVYRCD RVSNCPDNSD
     EFNCTCNPRE FRCANGQCIP SSARCDRKTD CVDRSDERNC PTCTSEQFTC DNGNCIDIRR
     KCDRRVDCRD GSDERDCPPR TCTSDQFTCE NGDCIDIRRK CDGRDDCRDG SDERDCAARC
     PGKFLCDVRR CIELSSVCDG RRNCNDNSDE KDCAPITCSS EQFTCTSGRC IDRERRCNRV
     NDCDDGSDES NCPCASGEIS CDGTCFPRER RCDGERDCSD GSDEQNCQGG TSIYVSPQQM
     KKRFGTSASF MCNVVGEQPS RITWIRRTGT GGSMPPQAVI TGNRLLIPDL RIEDAGDYLC
     QAFGSFGKIE AHARLEVEFD FYELSKVLLD CLKKNIRHSV NVSNAAHIQR DKGITNIGLV
     SLLSVVSLAF SAIDHLPCEP NEFRCDNGKC AMKIWRCDGD NDCGDRSDER NCEIEKPGSD
     CRASEFQCAS RDQCIPLGYQ CDGETDCLDR SDEVGCSKPT IITPPLPEIT VEINGTFTII
     CEAIGVPTPL IVWRLNWGNI PNGTRVTVTS ENGYGNLTIR NAIPQDAGAY TCEAVNNRGS
     IFAIPDANII VRRRTGVCRD STFNSEAYTE NQCVKCFCFG QTQSCYSSSL QISQITMGSQ
     VNLVRRQNLE AAEPGIVQYI PTSRQFEVKD FNSILRTGSW YWSLPHQFLK KQLNSYGGTL
     SYQVYYEVDG FENPTNDPDI ILIGNGITLF HRADVYERVD RRFRPRQSTI VNIPLNESAW
     ERSQVPSRGG PISQYATRED LMLVLENVTH ILIRATYDSK QSLIRLGNVV LTTGRVEQTG
     LGRAIYVEEC KCPAGYTGNS CEDCAPGFYR VVDGNNGRRC VACNCNQYSN ECDPLTGICR
     VSSKKHPINS SFLISLTLSH YDGSLVMWFE RSCFLDQDRE ITCRCPPGYT GRRCERCARG
     YVGDPSIPGQ FCYRQTDNVC DTRGSVSRLP NPLTGTCECK SSVTGTLCDT CKPETFYLSD
     ANPMGCIPCF CMGVTQICQS STWNRVPITL SFSQTSSDVT LTDVTQSEKI DEGFSIERQS
     RELVFTEFEN YNNKILFWSL PQQFLGNKVT AYGGNLRFTL RYKAGRDNTP VSLVESLVTI
     RGSEIDLEYK VNAEVEEGRP VSFVVPMIEN KWYKIDGNLV SRENFLMALA NLQHIFIRAT
     FTRDTAESAI SAISLDVAED RVTSRERAYQ VEQCACPLGY KGLSCEDCDS GYTRTGGGLY
     LGLCEECRCN KHSTECDPEN GVCKNCRHNT EGARCERCAR GYYGDATRGT VNDCQKCPCP
     LTESPNQFSS DCVLDRDRQV TCTACPVGHE GRRCERCAPG YSGDPMSPGD YCKQISVKCE
     CDDRGTMPNT ECDPRTRQCQ CKNNVEGRNC STCRTGYFNL NKDLDMGCLK CFCMGITNIC
     TSSYYYREEI TPVLDADGSH NFALVNGRLS RTVTDGFSVN AARNEITFNN FEGSQREQDS
     LYFNLPPKFR GDKVSSYGGY LKFTLRYTAS PTVGRDYTDL DVVLIGKQNQ KLYHVFRPQL
     RPRQINRYEI HLVEDSFQDS DLLTPSRETF LTVLADISAI LIRATYHHAM QSVTLGNLRM
     DIAGPNGRVA APEVERCSCP EGYSGLSCQS CAPGFVRVPD PRTALGRCAR CSCNGHSNSC
     DPATGVCQNC QHNTEGDRCE RCIRGYYGDP TSGTPNDCRP CACPLTIPSN NFSPTCVLDT
     SDNRITCDKC PPGYTGRDCG QCAPEYSGNP RQPGGKCQRI QQFEVEVSPK IVREPLGSTI
     RFLCTPRGRG PFNVVWSRLD GQALPSRATI GTGPGYELTI LDVDYTDAGR YVCSVTNPDG
     SNRDIGTLFV ERPDLPIKVR IQEPTRLVKR QGDQAEFICE AIQFNSAANY VLTWRKDGGQ
     LPSKAVEQSG VLYIPDLDQN DLGRYTCTGS QRGSIDSATA EIMFGEIPES PTVRIEPPSI
     RVQEGQRVEL VCVVTGSPRP TIKWTKGNTD ALPPHIITDR EGRLIIESVS PSDRAAYYCI
     AENYVGTSRT RATILVLPAT VARVIVRRAD IIAIVGQSEQ MVCETDGTGV TLQWSREGGL
     PPDVKPTSRI EPAEGLTIGS GTTGTLRCIV TGEPAPTIVW TRSRGPLSSN HQVRGDVLRI
     LQATPEDRDR YICTATNEAG VSVATVVVNI ERREPPLVTL YPSVSLIKRQ GESAMFQCRV
     TQGQPAPTVT WTRAGGLPLT ERTKVEQNGV LMFRDLTQRE QGEYICTSEN VVGSVSATAS
     LRVQGT
//
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