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Database: UniProt
Entry: A0A2C9K722_BIOGL
LinkDB: A0A2C9K722_BIOGL
Original site: A0A2C9K722_BIOGL 
ID   A0A2C9K722_BIOGL        Unreviewed;       430 AA.
AC   A0A2C9K722;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   03-JUL-2019, entry version 10.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:BGLB014359-PB};
GN   Name=106053857 {ECO:0000313|VectorBase:BGLB014359-PB};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|Proteomes:UP000076420, ECO:0000313|VectorBase:BGLB014359-PB};
RN   [1] {ECO:0000313|Proteomes:UP000076420, ECO:0000313|VectorBase:BGLB014359-PB}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BB02 {ECO:0000313|Proteomes:UP000076420,
RC   ECO:0000313|VectorBase:BGLB014359-PB};
RX   PubMed=15562597; DOI=10.1645/GE-284R;
RA   DeJong R.J., Emery A.M., Adema C.M.;
RT   "The mitochondrial genome of Biomphalaria glabrata (Gastropoda:
RT   Basommatophora), intermediate host of Schistosoma mansoni.";
RL   J. Parasitol. 90:991-997(2004).
RN   [2] {ECO:0000313|Proteomes:UP000076420, ECO:0000313|VectorBase:BGLB014359-PB}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BB02 {ECO:0000313|Proteomes:UP000076420,
RC   ECO:0000313|VectorBase:BGLB014359-PB};
RA   Warren W., Wilson R.K., Hillier L.W., Minx P.;
RT   "Sequence assembly of the Biomphalaria glabrata genome version 4.3.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:BGLB014359-PB}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|VectorBase:BGLB014359-PB};
RG   VectorBase;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_013064952.1; XM_013209498.1.
DR   GeneID; 106053857; -.
DR   VectorBase; BGLB014359-RB; BGLB014359-PB; BGLB014359.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000076420; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000076420};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076420};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     96    119       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    175    196       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       61    201       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      208    381       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   SITE        187    187       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   430 AA;  49456 MW;  EBA3C0CC1999D763 CRC64;
     MSQHSAGIKE AEVAGTLFLF ADPDEVKSRR KNWREILRRK CCFIRNYFHK EDPEDKRKSL
     VKKNGSYRVY MAGLNQHKRR YLADLYVTLI DLEWRYAMAV VFNVFLVSFL LFAVFWWLMA
     YNNGDFDNLN NPNHDFCLLG VTSFAGAILF SLETQTTIGY GMAYPNASCA ATLPLMYLQV
     VLGFFVETFM LGLIFVKIAR PKYRANTILF SKKAIINLEN GQLVLQIRLG DLRKSHLVDA
     SITGMIIRRH STPEGAYYPL YQFNCDFTAN GMGDKVFLLW PVILTHIIDK DSPLYDIRPP
     DLSSEKFELI LYLTGTVEST GETCQARTSY IPKEVLWGHR FERIEEYDIG HSRWHIDFAG
     FDDVVYCQNI RHSAKELDAI KESGTDHRGS DLSLAEGATS LTALRYDLTS KSTMYDHVTV
     PRSPRKERPY
//
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