ID A0A2C9K7U9_BIOGL Unreviewed; 444 AA.
AC A0A2C9K7U9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Acyl-CoA (8-3)-desaturase-like isoform X1 {ECO:0000313|RefSeq:XP_013096991.1, ECO:0000313|RefSeq:XP_055869417.1};
GN Name=106080202 {ECO:0000313|EnsemblMetazoa:BGLB016378-PB};
GN Synonyms=LOC106080202 {ECO:0000313|RefSeq:XP_013096991.1,
GN ECO:0000313|RefSeq:XP_055869417.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB016378-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB016378-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB016378-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_013096991.1, ECO:0000313|RefSeq:XP_055869417.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000256|ARBA:ARBA00009295}.
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DR RefSeq; XP_013096984.1; XM_013241530.1.
DR RefSeq; XP_013096991.1; XM_013241537.2.
DR RefSeq; XP_055869417.1; XM_056013442.1.
DR STRING; 6526.A0A2C9K7U9; -.
DR EnsemblMetazoa; BGLB016378-RA; BGLB016378-PA; BGLB016378.
DR EnsemblMetazoa; BGLB016378-RB; BGLB016378-PB; BGLB016378.
DR GeneID; 106080202; -.
DR KEGG; bgt:106080202; -.
DR VEuPathDB; VectorBase:BGLB016378; -.
DR OrthoDB; 294339at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR Proteomes; UP001165740; Chromosome 16.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016717; F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water; IEA:UniProt.
DR GO; GO:0042759; P:long-chain fatty acid biosynthetic process; IEA:UniProt.
DR GO; GO:0006636; P:unsaturated fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd03506; Delta6-FADS-like; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353:SF88; DELTA(5) FATTY ACID DESATURASE FAT-4; 1.
DR PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR PIRSF; PIRSF015921; FA_sphinglp_des; 1.
DR PRINTS; PR00363; CYTOCHROMEB5.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP001165740};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 119..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..95
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
SQ SEQUENCE 444 AA; 52255 MW; 8820B700F20F8F25 CRC64;
MGKGAQGESN GLIVKSKLEE FTWDVIKEKN TREEKWIVIE GEVYNITNWA RRHPGGPKVI
SHYAGQDATD AFKAFHNDLN FVKKYMKAIH IGTLKDSQHV VSPIEQDFRE LRETAEKMGL
FKPSILFFCL HMFHILFLDW AAWATMYYFG TGWIPYLASL LMITTVEAQT GWIQHDFGHL
SVFKNSKWNH ILHYFSVGII KGASPSWWNH MHYQHHAKPN VMDKDPDVRV EALFVVGDKM
PVQIAKKYKK SMPYNWQNYY FFLIGPPLLF PVYFQIMLFR YIFTRKAWMD LFVVTVFFTK
LFYLYTPILG FWSTVAFYFT FRCLESHWFT WVAQSNHVPM EIDHDKAMPW LPLQMQATCN
VEQSFFNDWF TGHLNFQVEH HLFPTMPRHN LYKIAPLVKS VCEKHGISYQ VKPLSTAFAD
IVRSLKHSGE LWYSTYQAYH ASTS
//
