ID A0A2C9K8F9_BIOGL Unreviewed; 1003 AA.
AC A0A2C9K8F9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=106075381 {ECO:0000313|EnsemblMetazoa:BGLB016496-PA};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB016496-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB016496-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB016496-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_013091783.1; XM_013236329.1.
DR AlphaFoldDB; A0A2C9K8F9; -.
DR STRING; 6526.A0A2C9K8F9; -.
DR EnsemblMetazoa; BGLB016496-RA; BGLB016496-PA; BGLB016496.
DR KEGG; bgt:106075381; -.
DR VEuPathDB; VectorBase:BGLB016496; -.
DR OrthoDB; 66005at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003949; K_chnl_volt-dep_EAG.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR10217:SF435; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01464; EAGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 32..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 282..334
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 437..537
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 608..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 929..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1003 AA; 112390 MW; E5C4E2F0B6249CCF CRC64;
MKGISTLFSA LKVVRLLRLG RVVRKLDHYL EYGAAMLVLL ILVFILFAHW FACIWYNIGW
SDLVNGVDYG WLPVLANTTK IKTMDQLPLL VIDSMVDVVF FVDIVLNFHT TFVGPSGEVV
SDPRIIRMNY LKSWFVIDLL SCLPYDVFNA FQYVDNVSPE RLYKAGLSKF ARLARSVTRN
RSTLLQFSSH QPSTKFDSSR PSQLANVSMM NLSADVLPQY RLEAPKTPPH IILHYCLFKT
VWDWVILVLT FYTAVMVPYN AAFKKGDNSF LLANARIVDY PIVYMNDGFC KLAGYNRAEV
MQKSSTCSFM YGELTDKETV KKVENCFEKL QHDQVEILLY KKNTLLYALI FSNVTTIFQQ
FYSSFARYHD MLNSVREFMK LHDVPKSLSE RVMDYIVSTW AITKGIDAAK VLNYCPKDMK
ADLCVHLNRK VFLEHPAFRL ASDGCLRALA MHFNMTHSAP GDLIFHQGES LDALCFVVSG
SLEVIQDDEV VAILSKGDVF GDNFWKEQSI GQSTANVRAL TYCDLHAIKR DRLLEVLDFY
HAFANSFARN LTLTYNLRHR LIFRKVADVK KEKELAEKRK NDPPLDLATD HPVRKLISRF
RKISDSKHDL KHSNSVDMER GGSANSNPGG GETSQQERPS SGTRLITVSE NPDQGANKPA
PRFGGGASRW SKFLPGSSSL AGQTSDQKAD SGEKAIPLND LSPKVETRSG EAPKISAKPM
AKWGRLLSKA QEPIEETPED EVRSNIKKNE SSDSAPRKNT NLDPPKDVRL EGESVQTNLN
INTLNSFSRD TTSNSSNGTN QSAGMPTGGL SAAEQHMLTS LYHIRLEMKE EMDGLRQKMN
RIDEHITEIL RYFSPASTPS SASTYPSSKF NSPLSLTHSN SEEQSPKTSI SSSPKHKPQE
DTAANVIQGQ ETTMNISNDS VLDKHQRLKL RPRPPTGLPQ DSDTKHKSPR RSSKSSNSSN
ESHKQTSGTP EPLPGRVHGA VQADVSEEGD ITPGKADEDL DVL
//
