ID A0A2C9K8W7_BIOGL Unreviewed; 1961 AA.
AC A0A2C9K8W7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Death domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=106059375 {ECO:0000313|EnsemblMetazoa:BGLB016595-PI};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB016595-PI, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB016595-PI}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB016595-PI};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_013072438.1; XM_013216984.1.
DR EnsemblMetazoa; BGLB016595-RI; BGLB016595-PI; BGLB016595.
DR VEuPathDB; VectorBase:BGLB016595; -.
DR OrthoDB; 5474900at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08317; Death_ank; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF33; ANKYRIN 2, ISOFORM U; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13606; Ank_3; 1.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 22.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 48..80
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 81..113
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 114..146
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 147..172
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 219..251
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 252..284
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 285..317
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 318..350
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 351..383
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 384..416
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 417..449
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 450..482
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 483..515
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 516..548
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 549..581
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 582..614
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 615..647
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 648..680
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 681..713
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 714..746
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 747..779
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1322..1477
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1482..1635
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1824..1907
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 878..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..999
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1177..1201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1961 AA; 216309 MW; 5D7DB2908B313530 CRC64;
MSATNIARRE QDETDGNAGF LRAARDGNLD EVLDYLKGST DINTSNPNGL NALHLASKEG
HINIVTELLS RGANVEAATK KGNTALHIAS LAGHEEIVRK LVENGAQVNL QAQAGFTPLY
MASQEGHADV VKFLLSVGAN QGLSTEDGFT PLAVALQQGH DKVVSVLLEH DAKGKVRLPA
LHIAAKKDDV KSAALLLQNE QNSVELQTKG GLVNDTTKSG FTPLHIAAHY GNINVANLLI
QRNADVNFRA KNNITPLHVA SRWGKLNMVN LLLDNNATID EKTRDGLTPL HCASRSGHES
VVDTLLEKGA PHSAKTKNGL TPLHMAAQGD HEDCARLLLY HKASLNEVTV DYLTPLHVAA
HCGNVKTAKL LLDRKCEPNA RALNGFTPLH IACKKNRIKV VELLLKYGAS IESKTESGLT
PLHVASFMGH MNIVIYLIQH NANPNTATVR GETSLHLAAR ANQSDIIRIL LRNSATVDAR
AREQQTPLHI AARLGNVDNV LLLLQHGASV DATTKDKYTP LHIAAKEGHE EVAQVLLEHE
AQHDITTKKG FTPLHIAAKY GNIKVARLLL QKEANPDISG KNGLTPLHVA THYNHANVAQ
LLLENKANPH ATAKNGYTPL HIAAKKNQMD IATMLLEYGA KPDAESKNGF TPLHLAAQEG
HTDIVSLLLE KQANVNATAT NGLTPMHLAA QEDRVQVAEI LIKHGSATDT STKAGYTPLH
TACHFGQVNM VRFLLDHEAS VNATTKVGYT PLHQAAQQGH VQVVNTLLKN QASPNAVTNN
GQTPLAIAQR LGYISVVEIL KPVTEVQGIT PSTEDKYKVV SPETMQETFI SDSEDEGGSS
FVGSFRSLQY GSLTISTFGG NESFLNLDDK RNSYLSTTSN LSREDSISLE RGGSASPLDT
SFDKEIHMRH KTTEHRGRQI SQMGATMYYP SYLENGPDYE EEMRYYHGDT LSPKDKQAAG
DKSRTDSVFY SGDYSTLGSN RDSLTLEGTR DRSMGDSTGD FMEEDDLKYV VADEAYLKKH
KPEDTFGEDL YARQSFRYGK RAPELTSPPR WSANQSFDSL QGSEVLLKDQ KASEAPAVQM
LPSAEYKERT AYQRSPSIEY KAKTETFLLQ KSPSVELKEK TAASIILESP SVEFKEKVVP
TIVLNSSLEK EVIEKVHKIE FTETTVTSVV KTSAKQSERV EKFTVEKPTP EKRKEPIQKQ
SSVDFKDSNL PSTERPHIIY QGQYSSSPDQ NSNIVKYLPD DSITAADASE FIQDYMDAQI
TSQSFSAMHT AAPPITGRLP VTGEVNRFSS YSGSSFSTSF DPDNVLVDRS PVYAGKLKWK
SFLISFMVDA RGGAMRGCRH PGVRVIIPPR KCCMPTRITC RLVKKEKLTK PPPMLEGEGL
AARVLEMGPA GTKFLGPILL EVPHFASLRG KEREVVILRS DNGETWYEHP TQATEDAVAE
ALGSSAEELD SEEDLSTKRI KRILTTDLPM YFALVSRVTR VKQESTVIGT EGGVLSSNVV
PQVQAVFPEG TLRRPIPVGL QAQPIAPELV AKLLGNRVAV SPIVTIEPRR RQFHKPITLT
IPVPKAAQKG MINQYGGERP TLRLLFSLAG NSSHGRADPN PAVWEDVTDS KPMTLVDDCV
SFTTKVSARF WLIDCQNVAE AAQMASILYQ EAVTVPYMAK FVVFAKRDSP EEGKLRIFCM
TDDKDDKTLE KQEKFYEVAR SRDIEVLEGR PQFVEMAGNL IPVTKSGDQL HVNFRAFREN
RLPCTVKIRD QDQEPSARVA FMKEPKVARG EAPQTPICNL NIRLPDMVLS DSGELDPDKS
AEIRKRHEFL RGQGFVIQDT VNRAEMKLSD IADTVQGDWV MLAQQLHISI SDINHFKNDY
KTVGDQALAM LHFWLQKNGD KATGNELENA LRRINRDDVV RKCMYNIERV EDEAEVEVAR
AIIEQTGLDS KDSLKRGMSL DVQYDEQDMI KNLDEIKVRL D
//
