ID A0A2C9K926_BIOGL Unreviewed; 1744 AA.
AC A0A2C9K926;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Sodium leak channel NALCN-like isoform X6 {ECO:0000313|RefSeq:XP_013075453.1};
GN Name=106061791 {ECO:0000313|EnsemblMetazoa:BGLB016593-PC};
GN Synonyms=LOC106061791 {ECO:0000313|RefSeq:XP_013075453.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB016593-PC, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB016593-PC}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB016593-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_013075453.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013075453.1; XM_013219999.2.
DR EnsemblMetazoa; BGLB016593-RC; BGLB016593-PC; BGLB016593.
DR GeneID; 106061791; -.
DR VEuPathDB; VectorBase:BGLB016593; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR Proteomes; UP001165740; Chromosome 15.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP001165740};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 879..901
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 921..942
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 954..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1015..1037
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1130..1153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1206..1225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1237..1262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1274..1291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1334..1356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1418..1444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..331
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 383..604
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 885..1158
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1206..1455
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 753..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1608..1699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1611..1635
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1640..1654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1677..1699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1744 AA; 200307 MW; 4F1108400DA81B86 CRC64;
MLVNRKTSFK DGMLMADYGP DENLNDNADI EWVNKSWVRL VLRLCAFVSM ISVSANTPET
FKEYPMLMTI TLILDLVIMM LFTAELVAKM RIRGVFKGEA PYMKDRWCRF DGIMVICLWG
SVILQIYEIA AHPGPESLAN NFRIIRAPRP LILVRVFRNF LKFQLPKNRI NSIFKRSSQQ
IYNVTIFFLF FMSLYGFLGV QFFGKMKHKC VRNGTDPSNV TLFDLAVPDT FCSPDPDAGY
QCQNDMVCME LAMSPAVMGF NGFDHLPLSV FTVYQAASQE GWVFLMYNSI DSLQSYKAYL
YFLSLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGSRG GTAESDASQV IQNDGGSWKL
VMVDENKTHG LAPPIFQQVL RSNFFHTFIL LLVLIDAVIA ASLSFDHHKK NPNEKFDIFY
YSEVVLTILF ALEAVFKIWC LGLHGYLKRS LHKFELVLVF GTTLHIIPEL YRSLMTSFQV
VRLFRLIKAS PILEGFCFKI FGPPKKLGSL ILFTMCLLII ASSISLQLFC FIPGFKKFQT
FKEAFMSMFQ ILTQKGWIEV MHVTMYNTGE KVAPFVAIYF IFYHLFVTLI VISLFVAVIL
DNLELDEDIK KLKQLKLREQ SLETQEMLPL RLRIFSKFPD HPQMVRLYKM PGEFQISDIR
ESFIRQFTSP EGSLSLVVDS QDQPENILPE LKSSHIKLIK SPMLETRSGG TVEKKSAIVG
IIRDANQQKI ISGGSAQLVP VGGRTMSILA HQHQIRMERS RSTRGGSRPT SLKLKAHPAM
KENGDINPHA TLMGVRRMDD LDIKDIQQKK QQAEQKRNQQ EVDLRENHPY FDTPLFLIGR
ESKVRKICEM IVNAKYDYVL RDPDTGKKIK SNYKQLHKLL GLVTYLDWVM IIVTILSCIS
MCFETPKKRI MENPELQVAE YVFVVFMSVE MGLKIISNGL LFTPNAVVND FRGILDLFIY
GVSIVFVFWM PKNIEPHSKE HILMLLRCCR PLRIYSLVPH MRRVVYELVR GFKEIVLVSV
LLIVLMFVFA ICGVHILGGR LAKCNDPNIT TKEDCHGIYL VEVLVTKMAL SPEPGNVPAM
YVPRAWINPR NFNFDNIGNA MLALFEVLSL EGWLEVRDVI SSRVGIAEAI YIHFFVFIGY
MIGLTLFVGV VIANYGENKG TALLTVDQRR WLDLKGRIKL AQPLHIPPRP ERNMFRTLVY
DITQHLYFKR FIVFLVIANC LMLSVPWKDD ANKSTMYILA GFSTAFTLLF FLEVIMKMIA
LSPAGYWTSR RNRFDMFVTL LGVIWIILHY SSSQSEHINS LGYIVIVLRF FTVTGKHATL
KMLMQTVVMS LFKALFIIMG MFLLMLFYAY AGVILFGSVK YGYNLGRQAN FETAFNAILL
LFRIVTGEDW NKIMHDCMVS TPFCSKGGNF WQTDCGNYFA SIVYFCSFYV IITYIVLNLL
VAIIMENFSL FYSNEEDALL SYNDIRQFQN TWNLVDINRK GMIPARRVRF LLRLLRGRLE
VDLERDRLLF KHMCYEIEKL HQGGEVTFHD VLSMLSYRSV DIRKSLQLEE SLAREELEFT
IEEEVAKQTI KNWLDKCLKR IRAREHSNII SNLRATNEPM FTVTELSLMN PDNKEENKED
GQAPPRTRKK GHVELRTPVI QPPSLSQAGS SRKFLTPPLN EGGTRSEKDR TSLRRRSCKA
SNSSNKQLPL VNENNSDSGT TTFIPNLTTD SSLVGKNVSS DISSWWKEQS TYTNLEEGVI
LENI
//