ID A0A2C9K9B6_BIOGL Unreviewed; 602 AA.
AC A0A2C9K9B6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Peptidase M12B domain-containing protein {ECO:0000259|PROSITE:PS50215};
GN Name=106065898 {ECO:0000313|EnsemblMetazoa:BGLB016693-PA};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB016693-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB016693-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB016693-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR RefSeq; XP_013080270.1; XM_013224816.1.
DR AlphaFoldDB; A0A2C9K9B6; -.
DR EnsemblMetazoa; BGLB016693-RA; BGLB016693-PA; BGLB016693.
DR KEGG; bgt:106065898; -.
DR VEuPathDB; VectorBase:BGLB016693; -.
DR OrthoDB; 3042901at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1620.60; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR InterPro; IPR041645; ADAMTS_CR_2.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF243; SOL NARAE, ISOFORM C; 1.
DR Pfam; PF17771; ADAMTS_CR_2; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..602
FT /note="Peptidase M12B domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012474418"
FT DOMAIN 226..449
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT ACT_SITE 392
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 391
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 395
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT BINDING 401
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ SEQUENCE 602 AA; 69292 MW; 5E1EA67753ED0213 CRC64;
MSNVVVIFSA IISHITGIEV MFQYEASDNT GDQMPDQFNV TFSTETKFLT KFNLRRAQSF
DVDIPLYTLD IDREGFFQSR KVKTAPRKDI GYYHDTNHKA VFCIKRSPET LSNNNSRFHL
KAVFQMDNSE YLFDSDDKTP KKPWRNLSLE MYSGPTRTES TTPRSRTTFD HYVYKLELLR
STTLDMFDTR IPPPEVEKTV RWTVINQSTS WSDPPSRRRR NTMRDYYVDE VALIDRLRFE
WFLEKANKDY YTARRNIQEH YAMMFSGIDM FYRGILNPLY TIHIRLCKIF VLETTYASSF
IDKYASDGKL NSQDALAALE KLFVGPGRAI IGFYDHVILF TGYDLFKYES SGEKVYTYAG
STYVGTMCRT DGTGCAVIED HRGPDIRIIA HELGHSLSAK HDGDGNDCSN SDRYIMNNGL
NRKQTPETKY NPWQFSACSV KYFTKFLTEN PSNSRRYHCL AYAIEASADI PDVSNKLLGQ
FIKPNQQCQL NYGNASYYCK GAENTQIEDI CHSMYCRDPL NSDDCKMMEA YIGTSCGDGK
ICLYGKCVSV PYAPQVDETC VFGDTKEDYC KSFISKFVGN CYQSKHYDLC CGTCNNMSRP
IR
//
