ID   A0A2C9K9L2_BIOGL        Unreviewed;       811 AA.
AC   A0A2C9K9L2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
GN   Name=106068332 {ECO:0000313|EnsemblMetazoa:BGLB016768-PA};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB016768-PA, ECO:0000313|Proteomes:UP000076420};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGLB016768-PA}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB016768-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_013083118.1; XM_013227664.1.
DR   STRING; 6526.A0A2C9K9L2; -.
DR   EnsemblMetazoa; BGLB016768-RA; BGLB016768-PA; BGLB016768.
DR   KEGG; bgt:106068332; -.
DR   VEuPathDB; VectorBase:BGLB016768; -.
DR   OrthoDB; 1003028at2759; -.
DR   Proteomes; UP000076420; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR024862; TRPV.
DR   PANTHER; PTHR10582:SF28; NANCHUNG, ISOFORM B; 1.
DR   PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF13606; Ank_3; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00248; ANK; 4.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        463..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        494..520
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        532..549
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        570..592
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        648..670
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REPEAT          173..205
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          241..273
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          274..306
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          466..680
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          777..811
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        783..799
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   811 AA;  92907 MW;  F96C1DC48163D32E CRC64;
     MGNTTVVATG VKNQGDAEAN KLYQLVDLKG GGELVEMAKV ARWTKNWADL DERIQRDVKP
     FLYHGGQGKY IPIVDLVKIR NKDRQKSGIK ASKNKQKSAQ DQARIDNIMQ LEINQIDGFL
     SRHGELETIL TLDMTXIRLA LANVKYVXKY LYENILHLAS DNFXILYNFF SFTGENILHI
     AIVNEDPAMV KFLLDKGVDF EARVCGNFFT PDDQKSSRTD SLDHEWVNVC KETNYEGNVY
     WGDYPLSFAA CLNQEECVRL LIAKGANPNL QDCNGNTVMH MLVIYDNMQM FDLLHSFGGR
     LDIKNRQNLT PLTLAAKLAR KNMYEHILEM VREVYWLYGN VTSAGYPLSD VDTISRTGEI
     NMDSALHLIV KGNLEGHLEM MDGVIVKLLQ EKWKTFVGFR FYRRFILFIL YFICFAVAFG
     LRRGENPCTT DQSSPLPSFC DLYSNQTEAD SCYLLVPYQV IDIARMTLES ITLVAAVIYI
     FLALKEIYHQ GFKVFFSTLT GAPAKTLFLM SCLFVIAMLP GRAACCPTFE DIVGVMAILC
     TAPYFLFFCR GFRIVGPSIV MIYNMIRRDL LQFFIIYVVF IIGFSQSVYV AFHSDPTCSN
     CTKLDNCTVF CNPMDAVVGM FSMSVGDFED LYSLFRGLPH PYRNTIKIIF IVYMIMVAIL
     LINMLIAMMA RTYEMVTNTQ KEWFRQWANI VLVVEQTVTT ESRRQQMIKY SVPFGDNERA
     LMIRWHQSEK EKEELKFIRN KNKISQKAMA SLKSRDRRSS IHSQPTRVET YIETMGNGKH
     QSSLQHNEEE VKEVHRSNSS IHVTEQTVNT T
//