ID A0A2C9K9Z4_BIOGL Unreviewed; 811 AA.
AC A0A2C9K9Z4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN Name=106057400 {ECO:0000313|EnsemblMetazoa:BGLB016852-PC};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB016852-PC, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB016852-PC}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB016852-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR RefSeq; XP_013070022.1; XM_013214568.1.
DR AlphaFoldDB; A0A2C9K9Z4; -.
DR STRING; 6526.A0A2C9K9Z4; -.
DR EnsemblMetazoa; BGLB016852-RC; BGLB016852-PC; BGLB016852.
DR KEGG; bgt:106057400; -.
DR VEuPathDB; VectorBase:BGLB016852; -.
DR OrthoDB; 25782at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15711:SF32; RAP GTPASE ACTIVATING PROTEIN 1, ISOFORM H; 1.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00390; GoLoco; 2.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50877; GOLOCO; 2.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 286..502
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 538..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 735..776
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 542..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 811 AA; 91233 MW; 0217F246561EC957 CRC64;
MTADMFFRNM EAMWRKRFHM HPAPEHDVID LHRKQSMEGQ LYCEAHAPPS QGSTPSPETD
EKNSDLFEML ERLQGTRIDD QRCDMTNFYK GPDFLDSLLL LQSRRYEDQR CLLPSPTKPD
QSPAPVVNED QRQNIQQILQ AGPPYPMIVL PPRGGYWMEG SEGFFTSEED NVHESISSLH
PSASELSIDT DFTAQCYRCE FYGKEHFNYY AFDEVVGPIV LSVKAESVTT DCINAIVRTR
FCTRQEILHS VSIEAPNPAK IAKCICDEIT TDRFHPVLSL KGSELVMSYD EHVLTHKFKF
GIIYQRKGQT SEEELFGNKT HSPAMDVFLD TIGDRVQLKN FKGFRGGLDT THCQTGAESV
YTQYNGKEIM FHVSTLLPYT EGDAQQLQRK RHIGNDIVAI VFQEENTPFV PDMIASHFLH
CFIVVQPVNS ESEPPRYKIS VAARKDVPRF YPLLPQPAEF VSGEDFRDFL LTKLINAELA
CYKADQFAKL GDRTRVSLLE SLYHDLHKRN LELYGITAAQ NPKQEGSRLL DSVKRAFSGK
GRSPSLESSA LTSQKKLNGL QGSLATVGED DKGTNSPVRK SPSTPRNLVR QYSSSFEKQP
KSNRDSKGNL RLDNSTHTGL NYQACASPPP SPQSSPSSVS STTRTNQLIL ISRSNSESSF
NSMEEFPAAN NNNNSNINNN IGNNGANNIK NSNLEDSDTG MVMESMSSTG TPNITTHNST
PYTGEYVFSL ESDVHDHLQR QIDQLRGEVH KLKSEKHDLL RQHAAQQKEI KSLKEQEMIL
TTELRSALHE LSAYKEGSVP TQIVMEDSSS A
//
