ID A0A2C9KA94_BIOGL Unreviewed; 2093 AA.
AC A0A2C9KA94;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 13-SEP-2023, entry version 32.
DE RecName: Full=Unconventional myosin-IXb {ECO:0008006|Google:ProtNLM};
GN Name=106064649 {ECO:0000313|EnsemblMetazoa:BGLB016873-PF};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB016873-PF, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB016873-PF}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB016873-PF};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_013078701.1; XM_013223247.1.
DR EnsemblMetazoa; BGLB016873-RF; BGLB016873-PF; BGLB016873.
DR VEuPathDB; VectorBase:BGLB016873; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd20818; C1_Myosin-IX; 1.
DR CDD; cd01385; MYSc_Myo9; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 2.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR046987; Myo9.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036023; MYSc_Myo9.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46184:SF5; HEAVY CHAIN, UNCONVENTIONAL MYOSIN; 1.
DR PANTHER; PTHR46184; UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00109; C1; 1.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 20..126
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 156..977
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1613..1662
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1679..1867
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 858..880
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1089..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1272..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1390..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1422..1458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1582..1605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1895..1921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2000..2023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1133..1156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1394..1408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1895..1916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2000..2016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 249..256
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2093 AA; 240427 MW; B383214ACAD0BD92 CRC64;
MAGHEFKPSN VQLIRRLSMD SYMVRVYAGP LNEEVESVAI EADKGTTAED VVGLACRKLR
LGGGDTKKHY ELAEVFSSGG QLCKERRLDS TESPVGLQLL WPKPNEIEPG KGLFDGYRFY
LRKRDPEVQP GGWVVTNQSA VDSFLMAFLT QPLAGKEFPD LCSLPDLNEK TLLYNLKSRF
NQKNIYTYVG SILIAVNPFK FFPIYNPKYV SMYQNKRLGE LPPHIFAVAD AAYHSMLREK
QNQCIVISGE SGSGKTESTN LLLHHLTALS HKGLHGSGVE QTILGAGPVL EAFGNAKTVH
NNNSSRFGKF IQVNYKQNGM VHGAIVEKYL LEKSRIVFQA KDERNYHVFY YLLAGADDKE
KESLHLLKAD QYNYLSQSAC YSVEGVDEKH EFSRLRQSME MVGFSPETQR KIFSVLSAVL
HLGNVEFKKK GDKHHDESVT IKAGDSVRII STLLKVKERY VLEALTQKKS TAGDETFVIN
YKMEDAVATR DAMTKCIYGA LFDWIVLKVN QALLAKKHDS EHEGDSIGVL DIFGFEDFGN
NSFEQFCINY ANEHLQYYFN QHIFKFEQEE YLREGIQWKN IEFIDNTGSL ELFSKRPSGL
FYLLDEECNF PAATNETLLN KFTHHHKSNP HYQVPQLREG AFSIMHYAGR VKYLVKDFRE
KNLDLVRPEI VDTLKKSSLA FVRELMGIDP VAVLRWSVVR AFFRCFFAFK KAGEVYRKNG
GKESRRRQKR ASDPTLQDVL NDNLLNSAAM GAHLQQHHLG HDPAVLLQRL HKEEVNDEIL
LYSSYGTNCS ESQVKVMRRT LRLLTKNKSF RPKPRPSLSF RDIKALKAIA SRTMPGSVRG
TGSKKQPPTV GAQFQWSLNC LMMTLNQANP YFIRCIKSNK DKAPCVFDEE LVMRQLRYTG
MLATVKIRQS GYNYRILLKE FTLMYKILLP VQTEFTKNDI SNFLTAKGLQ PENYQIGINK
IFLRETEKLK LDEALHSAIM KRVITIQKWV KACLERRYFL RIRESTILMQ KHIRRFLAQR
DFQQYQLYQL HTEAAIVIQT NFRRYLAWKQ FVSTRNAVVF LQAYIRTVLM RKRFLTLKEE
KRKKLLQDAE KERLESEKRQ KEEDKRRLEE EYEKIERQAQ ELLAKDYEEK LAKEENQSYE
ERLQLDRRKK EELQSTASDE GVLMKAPSTE ELEEDVRLPR RDSDESSGII EDSETESSEV
LSRPILDTPP TTPQSQRRDL SKTTPIKTSQ ERSRGRAQTS RVLDRYKPSQ TSEIVDGRKT
FVLPRSLHPT VRQKATAPLA RQESFSDREL TNATPEPMDT SNRPPPIHIP ERTTAYNDIN
IRDIENSLAQ NKKRNELEQL QDQQASSHLS PLHKAKKHWK NWMGEFKGHH TLPHSCIPSS
PGKTFKFFRH KSTKKKKEDS EEESEDSVSS LSRYSVESIG ISVLPASPQN KEPEEPSRFR
RNKKQNQNKV TSSSPARSRS NIRINEWQYA DNMVISDVDE LRKLDQFIGQ KIRELYDDSN
RRDTIFDRIF KGALEKFRKD LKTLIAVEVT KANPKVQYKE LFNQFRQVLT AEMKKMTDAP
IVMSVNAFRG FLDEFRKQEE SRLRENKKDG NRNQKKVVKK DKKKNEEIVE HNGHRYMQVD
FNIATYCEVC SSQKRIMEKG YVCQKCKQAI HKKCCSKMGA ACKGVADNKG RPNGQLFGAP
LDTLVSENQK IPLVCERLMS TIEMTGLYME GVYRKSGAAP KVKELQNALE MDVEAVNLEE
YPVHVLAATL KLYLRNLPEP LMTFELYDDF LRTMEIKEEK ELINSLFAII RKLPKANFDL
FERLVFHLAR VAMHSDSNKM SPNALAVVFA PVLLGTNKKL QAQDAIALVP QQMMCIEYVL
KEQMRTVKSK LDDIDTLESA EKTTGERLNA VRASLRTSRS PLSSPIKQQS VHANNENDSE
ILEENLEDEE YIEEDVKLKI EEKALSRHLA SIHKEKDKIT YKLPALETRQ VSSDEDMLSG
DEVDGDLDGE GQNEEYATGF EQPVTKSSLN HLSKTRTPAP HSRRLPQKFA KKVAASTKKP
LFEDTSEACL PEPIPVIQIR PQAQCSKYLS SMTVESSYVT IPSVAGEEDE IMV
//
