UniProt: A0A2C9KAP7

Database: UniProt
Entry: A0A2C9KAP7_BIOGL

LinkDB:  A0A2C9KAP7_BIOGL 
Original site:  A0A2C9KAP7_BIOGL

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (7)   
   RefSeq(pep) (7)   
Protein domain (3)   
   InterPro (1)   
   Pfam (1)   
   PROSITE (1)   
All databases (15)   

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ID   A0A2C9KAP7_BIOGL        Unreviewed;       303 AA.
AC   A0A2C9KAP7;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   Name=106060269 {ECO:0000313|EnsemblMetazoa:BGLB017014-PE};
GN   Synonyms=LOC106060269 {ECO:0000313|RefSeq:XP_055898892.1,
GN   ECO:0000313|RefSeq:XP_055898893.1};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB017014-PE, ECO:0000313|Proteomes:UP000076420};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGLB017014-PE}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB017014-PE};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_055898892.1, ECO:0000313|RefSeq:XP_055898893.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|RuleBase:RU079119}.
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DR   RefSeq; XP_013073530.1; XM_013218076.1.
DR   RefSeq; XP_013073531.1; XM_013218077.1.
DR   RefSeq; XP_013073532.1; XM_013218078.1.
DR   RefSeq; XP_013073533.1; XM_013218079.1.
DR   RefSeq; XP_013073534.1; XM_013218080.1.
DR   RefSeq; XP_055898892.1; XM_056042917.1.
DR   RefSeq; XP_055898893.1; XM_056042918.1.
DR   STRING; 6526.A0A2C9KAP7; -.
DR   EnsemblMetazoa; BGLB017014-RA; BGLB017014-PA; BGLB017014.
DR   EnsemblMetazoa; BGLB017014-RB; BGLB017014-PB; BGLB017014.
DR   EnsemblMetazoa; BGLB017014-RD; BGLB017014-PD; BGLB017014.
DR   EnsemblMetazoa; BGLB017014-RE; BGLB017014-PE; BGLB017014.
DR   EnsemblMetazoa; BGLB017014-RF; BGLB017014-PF; BGLB017014.
DR   KEGG; bgt:106060269; -.
DR   VEuPathDB; VectorBase:BGLB017014; -.
DR   OrthoDB; 6683at2759; -.
DR   Proteomes; UP000076420; Unassembled WGS sequence.
DR   Proteomes; UP001165740; Chromosome 9.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   PANTHER; PTHR22883:SF301; PALMITOYLTRANSFERASE ZDHHC12; 1.
DR   PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF01529; DHHC; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU079119};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU079119};
KW   Reference proteome {ECO:0000313|Proteomes:UP001165740};
KW   Transferase {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        43..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        176..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        214..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   DOMAIN          131..251
FT                   /note="Palmitoyltransferase DHHC"
FT                   /evidence="ECO:0000259|Pfam:PF01529"
SQ   SEQUENCE   303 AA;  35216 MW;  FFEC4689C30D8136 CRC64;
     MCAPKLRCSA ALVVRSLHTL IVLGVPATLL FKHSLLYQTL LGGQQLVLGA VYIAMWLWSL
     TMYYLTCLTN PGYIAVTKEN KASSLQLQMK QCISSDEEYD LKVAQNNNVD NDSSDENGHM
     LPADVSSGFK YRVCDYCEII QPMRAKHCED CNKCVRKFDH HCPWLEACVG ERNHRYFWLF
     LLSTFVLITC TFYITWNTFE YRIFWSDWIE VNAILFIDIF ILFIGGLVVM GLLGFHSYLM
     FKGLTTWEAA SRERITYLKY LDEDYNPFNE GLCRNLYHFL FACHLRKWEK VYARKAQGQN
     GIV
//

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