ID A0A2C9KBB0_BIOGL Unreviewed; 395 AA.
AC A0A2C9KBB0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Deacetylase sirtuin-type domain-containing protein {ECO:0000259|PROSITE:PS50305};
GN Name=106073429 {ECO:0000313|EnsemblMetazoa:BGLB017192-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB017192-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB017192-PB}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB017192-PB};
RX PubMed=15562597; DOI=10.1645/GE-284R;
RA DeJong R.J., Emery A.M., Adema C.M.;
RT "The mitochondrial genome of Biomphalaria glabrata (Gastropoda:
RT Basommatophora), intermediate host of Schistosoma mansoni.";
RL J. Parasitol. 90:991-997(2004).
RN [2] {ECO:0000313|EnsemblMetazoa:BGLB017192-PB}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB017192-PB};
RA Warren W., Wilson R.K., Hillier L.W., Minx P.;
RT "Sequence assembly of the Biomphalaria glabrata genome version 4.3.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:BGLB017192-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB017192-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR RefSeq; XP_013089426.1; XM_013233972.1.
DR RefSeq; XP_013089427.1; XM_013233973.1.
DR RefSeq; XP_013089428.1; XM_013233974.1.
DR RefSeq; XP_013089429.1; XM_013233975.1.
DR RefSeq; XP_013089430.1; XM_013233976.1.
DR RefSeq; XP_013089431.1; XM_013233977.1.
DR RefSeq; XP_013089432.1; XM_013233978.1.
DR AlphaFoldDB; A0A2C9KBB0; -.
DR STRING; 6526.A0A2C9KBB0; -.
DR EnsemblMetazoa; BGLB017192-RA; BGLB017192-PA; BGLB017192.
DR EnsemblMetazoa; BGLB017192-RB; BGLB017192-PB; BGLB017192.
DR EnsemblMetazoa; BGLB017192-RC; BGLB017192-PC; BGLB017192.
DR EnsemblMetazoa; BGLB017192-RD; BGLB017192-PD; BGLB017192.
DR EnsemblMetazoa; BGLB017192-RE; BGLB017192-PE; BGLB017192.
DR EnsemblMetazoa; BGLB017192-RF; BGLB017192-PF; BGLB017192.
DR EnsemblMetazoa; BGLB017192-RG; BGLB017192-PG; BGLB017192.
DR GeneID; 106073429; -.
DR KEGG; bgt:106073429; -.
DR VEuPathDB; VectorBase:BGLB017192; -.
DR OrthoDB; 1947602at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.20.28.200; -; 1.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR003000; Sirtuin.
DR InterPro; IPR026590; Ssirtuin_cat_dom.
DR PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR11085:SF2; NAD-DEPENDENT PROTEIN LIPOAMIDASE SIRTUIN-4, MITOCHONDRIAL; 1.
DR Pfam; PF02146; SIR2; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR PROSITE; PS50305; SIRTUIN; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00236};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00236}.
FT DOMAIN 100..377
FT /note="Deacetylase sirtuin-type"
FT /evidence="ECO:0000259|PROSITE:PS50305"
FT REGION 375..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 214
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 222
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 225
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 248
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT BINDING 266
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
SQ SEQUENCE 395 AA; 44545 MW; 0CFCBF0C4BA366E1 CRC64;
MAASSLQTSF KCNYSLCPKK FILSENEARV QVRAFEPKSP VKLLAVNWQE NATAVFHYDC
WETLLRAAKH TDSQDQTYLS LTEIEMILEA KKTAEYFDSL ERVQAQALHI AEIIRKSQYC
IAFTGAGIST AAGIGDFRGV DGKWTNLDKR KLYGAKSAKS GSSRTNLIDL RPTYTHEALF
KLLEMKLLKF IISQNTDGLH LLSGVHPDQI AELHGNSFVE KCEKCHSRFQ RTFPVRMHQT
GVCPPKPCPK CNINHRTGRK CSKPECEGCL MNTIINFGDH LETPVLNKAK KEAEQADAVL
TLGSTLMVFP ANELVTCGPE PHRLIICNRQ ITAYDEECYK TGKDGKQLGS RVFGNCDNLM
KEVMKRLMPK AELDQWEASR SSRMKEYSKK RGPEI
//
