ID   A0A2C9KBH1_BIOGL        Unreviewed;       704 AA.
AC   A0A2C9KBH1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=galactosylceramidase {ECO:0000256|ARBA:ARBA00012657};
DE            EC=3.2.1.46 {ECO:0000256|ARBA:ARBA00012657};
DE   AltName: Full=Galactosylceramidase {ECO:0000256|ARBA:ARBA00033098};
GN   Name=106050916 {ECO:0000313|EnsemblMetazoa:BGLB017236-PC};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB017236-PC, ECO:0000313|Proteomes:UP000076420};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGLB017236-PC}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB017236-PC};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 59 family.
CC       {ECO:0000256|ARBA:ARBA00005637}.
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DR   RefSeq; XP_013061433.1; XM_013205979.1.
DR   AlphaFoldDB; A0A2C9KBH1; -.
DR   STRING; 6526.A0A2C9KBH1; -.
DR   EnsemblMetazoa; BGLB017236-RC; BGLB017236-PC; BGLB017236.
DR   KEGG; bgt:106050916; -.
DR   VEuPathDB; VectorBase:BGLB017236; -.
DR   OrthoDB; 5487508at2759; -.
DR   Proteomes; UP000076420; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004336; F:galactosylceramidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006683; P:galactosylceramide catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR049162; GH59_C.
DR   InterPro; IPR049161; GH59_cat.
DR   InterPro; IPR001286; Glyco_hydro_59.
DR   InterPro; IPR035394; Glyco_hydro_59_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR15172; GALACTOCEREBROSIDASE; 1.
DR   PANTHER; PTHR15172:SF1; GALACTOCEREBROSIDASE; 1.
DR   Pfam; PF02057; Glyco_hydro_59; 1.
DR   Pfam; PF21708; Glyco_hydro_59_C; 1.
DR   Pfam; PF17387; Glyco_hydro_59M; 1.
DR   PRINTS; PR00850; GLHYDRLASE59.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        5..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          61..354
FT                   /note="Glycosyl hydrolase family 59 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF02057"
FT   DOMAIN          363..480
FT                   /note="Glycosyl hydrolase family 59 central"
FT                   /evidence="ECO:0000259|Pfam:PF17387"
FT   DOMAIN          517..687
FT                   /note="Glycosyl hydrolase family 59 C-terminal lectin"
FT                   /evidence="ECO:0000259|Pfam:PF21708"
FT   ACT_SITE        204
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601286-50"
FT   ACT_SITE        279
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601286-50"
SQ   SEQUENCE   704 AA;  79114 MW;  0B3A67D90FFE578C CRC64;
     MQQKAFGLTW TSLILSLIIF VIIKTSKSNQ LGYKDQYLVS NTSRTDQDLV FDDFLGFGRT
     FDGVGGLSGG GATSKLLVNY PLQQQNEILD FLFKPNFGAS LQILKVEIGG DVQSTDGTEA
     SHMHNDWDEN YERGYEWWIM TEAKKRNPNI KLYGLPWGFP GWIGQGTRSP FAKVNVTADY
     IVRWVNGAKT HYNLSIDYIG IWNEKKYDIT YIKVLREMLN QRGFQNVMII AADKKWEIAV
     DIEQDPVLAS SVHAIGCHYP GTYSTQEALN TNKQLWSSED YSTLNDEVGG GCWARILNQN
     YVNGLMTSTI SWNILASYYQ GLPFFRDGLM TAINPWSGYY EVNTPIWMTA HTTQFTSIGW
     RYLKHDSGVG KLPQGGSYVG LVSPDGTDLT IVIETMTRNH SKCIRPYLPN YEVKPQQVTI
     TLKGSFVNVT QLNVWYSKLG FNSSPDIVFE KQKPIQLING HAQINLGLDE VVTLTTLMRG
     QKGYYPQPPQ QKSFPLPYSD NFEAYRISEE PFLLVPQIGS LEIIKSQSPL HGQVARQTIL
     YPPIEWCPFS LSFPIAVIGN ISWSDLFIQI EFEIPEINGT TGVFIATRVD TGGCTTFIAQ
     GIFFFLLKDG SYILANDLAR TKVWKQGLFS YQPGFHKVSL LTQGTQAIGF YDDQLLFNVT
     VSGNLSQGFA AIGTDSFGWA DFDNLLLTSQ ADGIAILNKY HEIV
//