ID A0A2C9KC89_BIOGL Unreviewed; 866 AA.
AC A0A2C9KC89;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Calpain-B {ECO:0008006|Google:ProtNLM};
GN Name=106056965 {ECO:0000313|EnsemblMetazoa:BGLB017489-PC};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB017489-PC, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB017489-PC}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB017489-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR RefSeq; XP_013069382.1; XM_013213928.1.
DR AlphaFoldDB; A0A2C9KC89; -.
DR STRING; 6526.A0A2C9KC89; -.
DR EnsemblMetazoa; BGLB017489-RC; BGLB017489-PC; BGLB017489.
DR KEGG; bgt:106056965; -.
DR VEuPathDB; VectorBase:BGLB017489; -.
DR OrthoDB; 142935at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR CDD; cd16196; EFh_PEF_CalpA_B; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF379; CALPAIN-A-RELATED; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF13405; EF-hand_6; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 164..463
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 767..802
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 83..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 219
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 375
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 403
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 866 AA; 97231 MW; 5BF1B0B4533DFA3E CRC64;
MSNYYKTKTI RTYVSDGTGA PKVQTKTVTI GGPGGSSIGF TPSSDFGDFG NFGSRGFDDF
GGQFKIDFGD SFGGKGFGFD IGNKGGSRPS GGGSRSYVIG GGDADPGRRT GGSTIKVVAP
PTDPDPQPKL AGRPTRVLKK NPFVGLKFQN PDEIRAQCLR EGILFEDPEF PCVDSSIFFS
RSPPRPFEWK RPHEICDNPQ WISQGASRFD VRQGELGDCW LLAAVASLTC NPKLFENVVD
SRQTFTENYC GLFKFKFWHQ GEWQEVVVDD RLPTYRNQLV FMHSTEKNEF WSALLEKAYA
KLMGSYESLK GGSTSEAMED FTGGVTEMFD LQKAPPNLLN IMLKANERGS LMGCSIDADP
GRVEAELANG LIMGHAYSVT SVVLADIKTA RVKGQIPLVR VRNPWGNGSE WKGAWSDGSR
EWSLLTEDEK QEHGITFSDD GEFWMSFQDF TANFQKLEIC NLGPDSLDEE DLSNKKKWEC
FKEHGAWIKR VNAGGCRNYL DTFWTNPQFR MTLTDVDDDD NDDMCTAIVA VLQKDRRKKR
KEGLDLLTIG FVIYKLEDPN CGPLDMKFFK YNPSVAKSPT FINMREICGR FKLPPGSYAI
VPSTFEPHYE GEFLIRIFTE KANVSGEIDE QTSLDDDVYV TPERFPQRAA AAPGKDAAFT
AQKVAPASNH PQAKNAPKQK YERTEPTDQE RAQADALKQS FKRIAGEDME IDAYELQEVL
NTVFTKEDTF EFTFPGFGVD TCRSMVAMHD GDLSGKLGYD EFKDLWEDLR RWKGVFKEFD
KDKSGNLSSY ELRNALNHVG FHISNRTFKS LVMRYSNKNG QIDFGDFIMC TIRLKTMLTS
FRGHDPQNTG FAPYDIDSFI QTTMYS
//