ID A0A2C9KCM4_BIOGL Unreviewed; 829 AA.
AC A0A2C9KCM4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN Name=106069088 {ECO:0000313|EnsemblMetazoa:BGLB017574-PF};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB017574-PF, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB017574-PF}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB017574-PF};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the IAP family. {ECO:0000256|ARBA:ARBA00006672}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013084119.1; XM_013228665.1.
DR AlphaFoldDB; A0A2C9KCM4; -.
DR EnsemblMetazoa; BGLB017574-RF; BGLB017574-PF; BGLB017574.
DR VEuPathDB; VectorBase:BGLB017574; -.
DR OrthoDB; 5406876at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0043067; P:regulation of programmed cell death; IEA:UniProt.
DR CDD; cd00022; BIR; 1.
DR CDD; cd16713; RING-HC_BIRC2_3_7; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001370; BIR_rpt.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10044:SF139; DEATH-ASSOCIATED INHIBITOR OF APOPTOSIS 2; 1.
DR PANTHER; PTHR10044; INHIBITOR OF APOPTOSIS; 1.
DR Pfam; PF00653; BIR; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00238; BIR; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 2.
DR PROSITE; PS01282; BIR_REPEAT_1; 1.
DR PROSITE; PS50143; BIR_REPEAT_2; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 782..817
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 127..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 92999 MW; AD48534BD5A033B2 CRC64;
MSITDNIMCP TTLLAFLELE LEVIESLCRL CRSRLILDLD TILKALNDVT NQINNTKKPE
EFHYTPINVE VVHLYKLHRE NQLFFSCLVN LQTSEKHFKP NSLKQKITFP LRHLRQNDAL
KKKKLFVKEK NRKSQNNERD NSRFNRSNLC NHKSRLKLNT EEERFKKNGS NNYDQKTRID
SCFISLEKRN SVETLEKDKE IDLIASIKKD CKFKDVDVSS RKRLHHSFGE SHISERENEW
WKDLLSTKNF KLKPCNISVY IVDKVSRHPA RLGNIQWSWL VEEVWRIRTF SNYPQNAAKS
AILLASDGFA YMGSGRDLDD SVICFFCESV KNKWQPLDDI CEVHTQLSPN CSMVTHINCP
NIPLKTNHDS SLFDKVFQIQ KYHRNLNASE NRNSIQDIEH DGEITATNRS NLPVSSQAVP
EHPRSIAAPP SQSSRADDSS QILSSASPSV RESPSNAVSS IPISVSNNTT PRGNTVLPTA
NNLVSDSSTL VTVSESSTDT TVSSTDTAAP STNTAAPSTD TAAGHSSATA STSNTVNQAV
ANSSQNATKG NAGGPTYSEL GIVTERPKRF EYAVLLKRME TFLSWPRDHH LRPKELAEAG
FYYAGYGDCA RCFYCGGGLR NWEDEDDVWV EHARWFPKCA YIRQQMGQVF VDIVQELNKT
NDHIPFKMVM EKIGDAASSF QLDSKDNPLK RDPAVKTIVD MGFPLAEVIA KAEAIKDDGN
ILSADKIYEK LMADNVKKSA SGLKISGATS SVAVPAAVVA KDIEKLRTLK EQNNQLRQQT
VCKICMDKEV AVVFLPCGHF VSCTDCAAAM KDCPVCRNHV KGLVRAFMS
//
