ID A0A2C9KD65_BIOGL Unreviewed; 656 AA.
AC A0A2C9KD65;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN Name=106058011 {ECO:0000313|EnsemblMetazoa:BGLB017684-PB};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB017684-PB, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB017684-PB}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB017684-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR RefSeq; XP_013070849.1; XM_013215395.1.
DR AlphaFoldDB; A0A2C9KD65; -.
DR EnsemblMetazoa; BGLB017684-RB; BGLB017684-PB; BGLB017684.
DR GeneID; 106058011; -.
DR VEuPathDB; VectorBase:BGLB017684; -.
DR OrthoDB; 374620at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017050; F:D-erythro-sphingosine kinase activity; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 206..350
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 430..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 656 AA; 72671 MW; 1019F49862519286 CRC64;
MTLAWSHDFL GFKMAALMDQ VLLEGEFMLF PKKKGIYKLT LTRRGLYYSP VSNSNTVYEE
KCILISDIVG CRCLEKGGNV TLQGAILPSS PSLPTSNSTD SNPKTKDAKV YLQKEPEHLT
FPSNYFLRAP DSDTHGFVVY AYPFKKKLFS SKTSRSRLVV AFEMAHSSVD LLEEKKKETL
KWQKVISLLA RDPHIAKEDT SSSVQTPQGK LLVLINPHSG PGKAYTIFKS EIVPMLYEAN
IPYTAVITDH AGHASELMKE ICLSDWYGVV IVSGDGLIFE TINGIMQRDD WASSINVPIG
CLPGGSGNAL CCSINYAAGE PLDPMVLHST FILAKHRVVP MDLVIVQIPN RSIFSFLSVT
WGIMADIDYE SERYRNLGEA RFTLGAIKRI VSLRTYRGRI SFLPVAEYTP NEMMKPKKVL
TKVRRFSLRS RSNSKNTLDN GDSESSPRLS TKRSFNTEIS ENGLADGNQP CGEVGLVGTR
KTEDGSGDMT PNAQRVDSDN MIILSETQEL RVEKETYSGK KSDFSPVPTP LLPPLNQDVP
ENWVQLEGGF VLIAAVYQTH LGSDMLAAPE AHLCDGHINL MMVREGISRN ALLNLFLSFG
QGGHVHSPYV ESVKVLAFRL EPETKTGNIM IDGERFEPCS LQAQILPGLA RVMAIK
//
