ID A0A2C9KDY4_BIOGL Unreviewed; 952 AA.
AC A0A2C9KDY4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN Name=106071055 {ECO:0000313|EnsemblMetazoa:BGLB018030-PA};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB018030-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB018030-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB018030-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_013086542.1; XM_013231088.1.
DR AlphaFoldDB; A0A2C9KDY4; -.
DR EnsemblMetazoa; BGLB018030-RA; BGLB018030-PA; BGLB018030.
DR KEGG; bgt:106071055; -.
DR VEuPathDB; VectorBase:BGLB018030; -.
DR OrthoDB; 1220385at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 41..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 913..952
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
SQ SEQUENCE 952 AA; 107683 MW; 41BE219FAFA37F25 CRC64;
MEMNNGSNIS LHLERLFMDI FKVKEDDPFH TDTILDTQRD FLYLCFIFLV GAVVRHATDV
LVIPLPYTVV VFFVGVIAGY LPLGQVVEIG PHTIIYVFMP ILIFEGSFAI DTYIFKQIFI
QVLILAVPAL VVMTVLLATT SLYLFKYDHW GWLVALLFGS ILSATDPVAV VAIMKELGTN
KRLALLIEGE SMLNDGTAMV CYELIQHILE DPSTTVDSMI YQMLWVTVGG ALFGYIMAKL
AIFWLQWTFN DSLTEIAITL SMAYLVFYIS DAYLKISAVL GVVTLGATLG EHRTSISPEV
EVFLHSFWET LSFMANTLIF ALCGFIITKK VIIFAELQDC IYVIILYFAV NVIRGLTFMM
FSPILKRLGY GLTWQDGLVC TWSGLRGAIG LALALILFKS EDPILSQPSV GGKILFHVSL
IVVATLLINA TTVSHLLTFL GLTDVTPARR NAMKKAIGIL DECRRKTMNV WKIDRFLADA
DWEIVNTVCT IEDPFTSSET TEEKELRERQ GGICPKCGTV IPYVPTASEV HKWLAEATRK
YLKLLKQNFW LQFERGLLAG FSVRKLIELA EEASDRDCEM IKVGGIKNMW KIPNCIATSK
KILKSQKLMH AVYKMKKIQE TRSMTVNIIY HLSQCQFLMA GIFGMDTAII IATQVFLFLK
WSSSNTEIGL QHANIVMTVF LTLYFILRLC LFKFAYVKTA WFYFNLVSLI QAYVDITVGW
FAFQEFAHNL LFDDSIEREL TSKVLISLRV IRIFQLLELL VSILLNLIKH YIRERLTTGC
DMGRGFVRAN ELAIRLVDHI SDDVNVQNMI RESAEKAKMS VLRELGMLFG PKGTREQVLS
SWSSQPQTIS LHPAEGLGSK DVILFSREET CQIIESKMKR LMAAPPILEI PSTKKILAAI
PWIDGDYQLV DYIYHLAQEK LYNYGEVILR HGEPPDGIYF IMSGLVKATN KV
//
