ID A0A2C9KG36_BIOGL Unreviewed; 429 AA.
AC A0A2C9KG36;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Tumor susceptibility gene 101 protein-like {ECO:0000313|RefSeq:XP_013094382.1};
GN Name=106078154 {ECO:0000313|EnsemblMetazoa:BGLB019148-PA};
GN Synonyms=LOC106078154 {ECO:0000313|RefSeq:XP_013094382.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB019148-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB019148-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB019148-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_013094382.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV
CC subfamily. {ECO:0000256|ARBA:ARBA00009594}.
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DR RefSeq; XP_013094382.1; XM_013238928.2.
DR AlphaFoldDB; A0A2C9KG36; -.
DR STRING; 6526.A0A2C9KG36; -.
DR EnsemblMetazoa; BGLB019148-RA; BGLB019148-PA; BGLB019148.
DR GeneID; 106078154; -.
DR KEGG; bgt:106078154; -.
DR VEuPathDB; VectorBase:BGLB019148; -.
DR OrthoDB; 37962at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR Proteomes; UP001165740; Chromosome 6.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.140.820; -; 1.
DR Gene3D; 6.10.250.370; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR017916; SB_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR23306:SF3; TUMOR SUPPRESSOR PROTEIN 101; 1.
DR PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1.
DR Pfam; PF05743; UEV; 1.
DR Pfam; PF09454; Vps23_core; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51312; SB; 1.
DR PROSITE; PS51322; UEV; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP001165740};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..145
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
FT DOMAIN 361..429
FT /note="SB"
FT /evidence="ECO:0000259|PROSITE:PS51312"
FT REGION 144..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 279..351
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 150..170
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 429 AA; 48006 MW; 62202BC6E670E11F CRC64;
MAQYDAALRQ YLSKYKHPNE AKADILKTIN QYRDLRPSLD PFVFNDGTER QLVQLEGTIP
VNYKGNTYNI PISIWVIDTH PYNPPMVFVK PTSTMQIKSG RYVDTNGKVD MPYIREWRHP
TSDLLSLVQV LALVFGEECP VFSRASGPRP QQPLPYPGQP PYPNNPSSMP PYPVTTGVGP
GYPGGYSAPG YPGYPNNQAG YPAAGYPSYP PQYPASSYPS GYPGQAGGYP PQFGTQPPYP
PNSITTDGAS DMSRLTQGGT VTEADLRASL LSAVEDKMKR RLRETFAQAQ AEMDVLKKTQ
KDLTTGKERI EIIITELEKE KADIEKNIEL LREKDNEVKE AIQKMESNQN LSIDDAVVTT
TPLYRQLVDA FAEEQAIEDA IYYLGEALRK NVIELESFLK RVRELSRKQF MLRATIQKCR
EKAGLPPLA
//
