ID A0A2C9KGR8_BIOGL Unreviewed; 634 AA.
AC A0A2C9KGR8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Kinetochore protein NDC80 {ECO:0000256|RuleBase:RU368072};
GN Name=106071648 {ECO:0000313|EnsemblMetazoa:BGLB019513-PA};
GN Synonyms=LOC106071648 {ECO:0000313|RefSeq:XP_013087258.1,
GN ECO:0000313|RefSeq:XP_055889504.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB019513-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB019513-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB019513-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_013087258.1, ECO:0000313|RefSeq:XP_055889504.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|RuleBase:RU368072}. Nucleus
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family.
CC {ECO:0000256|ARBA:ARBA00007050, ECO:0000256|RuleBase:RU368072}.
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DR RefSeq; XP_013087258.1; XM_013231804.2.
DR RefSeq; XP_055889504.1; XM_056033529.1.
DR AlphaFoldDB; A0A2C9KGR8; -.
DR STRING; 6526.A0A2C9KGR8; -.
DR EnsemblMetazoa; BGLB019513-RA; BGLB019513-PA; BGLB019513.
DR GeneID; 106071648; -.
DR KEGG; bgt:106071648; -.
DR VEuPathDB; VectorBase:BGLB019513; -.
DR OrthoDB; 25325at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR Proteomes; UP001165740; Chromosome 6.
DR GO; GO:0031262; C:Ndc80 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.250.1950; -; 1.
DR Gene3D; 1.10.418.30; Ncd80 complex, Ncd80 subunit; 1.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR PANTHER; PTHR10643; KINETOCHORE PROTEIN NDC80; 1.
DR PANTHER; PTHR10643:SF2; KINETOCHORE PROTEIN NDC80 HOMOLOG; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368072};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU368072};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU368072};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU368072};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838, ECO:0000256|RuleBase:RU368072};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU368072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368072};
KW Reference proteome {ECO:0000313|Proteomes:UP001165740}.
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 262..386
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 477..564
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 36..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 634 AA; 73055 MW; F6C4234FE8119D5F CRC64;
MRKSSIGGPP QRVRADNTTH SRNPSRERPS LIGRPSISGY GNSRLSSYGN QRQSSVNQFS
AIPKLGRPSS GIGVRGRTDV IKDTRPIYDK KYQAQCIRQL LEFLISHQYP HPISQKLLEL
PSAKDFFKIF EFCVGQYWFG YKQVPKMEEE VPRVLKLIGY PFTISKTQLM SAGSPHTWPH
LLAALIWIIE TLPMTALNIE NHGGIDAFIF ETSESETVSL EKIIFDDSVR TYLAFMSGAD
TFEEQNTCVE KILLHKLQGF NVEELNDENT RLETELALME QTKKKRRKIQ EAIENLKCDF
KLLSAHVSNL RDYRKNIAAE NKTLEDELGM LSANLQSERE KLTKLQEVYE KQSLSPADVE
RLKAEQDSLK LEVDKLEKAI ANIDADIWEK SMKQAKINEE VEKEASTYNR IAIGLKLVPE
TTELARGRDF RLYSGFSSDP VGAFDNTVKP MLLTLKKSTE DSIRKKEKYL FQLKGDNEQC
SEGLTELKAN LEKVEKELHS LDEEIESLKK LSQSDKMSVT NEIESVQQEI RNLEDRQRQV
LEEKDRLTEE LKRLTAIENV KKEEVVELTA TLDKDYTKIC NDAEDYKNSV EQQMDIYTET
LRAKVMTKRA HIKQLQEESR DRERRLDLMF KNLH
//
