ID A0A2C9KJ26_BIOGL Unreviewed; 799 AA.
AC A0A2C9KJ26;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=PDZ domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=106058326 {ECO:0000313|EnsemblMetazoa:BGLB020256-PH};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB020256-PH, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB020256-PH}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB020256-PH};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013071173.1; XM_013215719.1.
DR RefSeq; XP_013071174.1; XM_013215720.1.
DR AlphaFoldDB; A0A2C9KJ26; -.
DR STRING; 6526.A0A2C9KJ26; -.
DR EnsemblMetazoa; BGLB020256-RH; BGLB020256-PH; BGLB020256.
DR EnsemblMetazoa; BGLB020256-RK; BGLB020256-PK; BGLB020256.
DR KEGG; bgt:106058326; -.
DR VEuPathDB; VectorBase:BGLB020256; -.
DR OrthoDB; 2875542at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR PANTHER; PTHR45872:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF09128; RGS-like; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 119..183
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 703..753
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 18..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 265..292
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 26..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 799 AA; 89002 MW; 592108EDFFB4AD25 CRC64;
MPLNRKWRSM DLFGSRESLN KLPFLNHGNK DKDHGNKDKD HGNKVKDSKE GHLKHEHPAE
LRPPKGNSKN RLSQRGVEPN GMGRLYLRRL SSLTPGSDSN AGSSRNVEPA DPASLVQRCV
IIQRDEKGYG FTVSGDNPVF VASVKADGAA SKAGVQQGDR IVKVNGTLVT SRNHLDVVKL
IKSGSYVALT LLGKPHPSGA INTPSIIASS KRDSVTGQVV TAPQPVDPEK DKELWNQKVV
MTRTMYETAK EDYNMLQRQY VVKPTDKLYN QLLEKERTYR ALEQQLKQLT GEDKLHSAIT
SISHPPVPEH GSIDNTWLHR SGSPSNIRHS KQSSVPSLAS SSAGESSLAE MRGVQVARSK
SDVATRNKKS SSVFYVDNQG FKDSEAKKRY FHLKRASSVP TTTSEFGSVY DSPQTSPSVS
PTPNGQESVD TMSTDIITID DEEVHSEDEQ LLAAVSPWVG GRPTTPIGTK ITGPEMNNPG
PFADIKLLES KPAHLAVFLN YLFHNLDPSP VLFHLISDQY SRCTANSKEL RKYAYEIYST
FIAQNAPLSV CDDDILISQM DNILNISATK TDNDIALRTM FQPVRQNVQN EISELLSDFR
SKKDLGMLNF YGYGKLQDNM DKNMEIKAAE ETLIPVISSL GVEDNVRVEK DQAIVWAFAT
FLRSWVGTKS SHPTLERVQT FMMKEKKSIR IPMRSSKAKE VKGHQFILQH FFVTTNCNCC
GGLLWGVGFQ GYQCQTCKMP LHKQCVENIT EPCGGKLKRK DRPLSKPPPP KKPTSKSLFS
QRYFSVLLKR CNSTAKMRH
//
