ID A0A2C9KM76_BIOGL Unreviewed; 1191 AA.
AC A0A2C9KM76;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=106060028 {ECO:0000313|EnsemblMetazoa:BGLB021313-PA};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB021313-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB021313-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB021313-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR RefSeq; XP_013073206.1; XM_013217752.1.
DR AlphaFoldDB; A0A2C9KM76; -.
DR STRING; 6526.A0A2C9KM76; -.
DR EnsemblMetazoa; BGLB021313-RA; BGLB021313-PA; BGLB021313.
DR KEGG; bgt:106060028; -.
DR VEuPathDB; VectorBase:BGLB021313; -.
DR OrthoDB; 7959at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07595; BAR_RhoGAP_Rich-like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR PANTHER; PTHR14130:SF14; RHO GTPASE-ACTIVATING PROTEIN 92B; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1..233
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 239..425
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 505..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 153..180
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 682..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1076
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1184
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1191 AA; 130175 MW; 9F73F0C1BB526BDA CRC64;
FRAEKSEVLS EDQQENEKRV ELVKHAFQNV TKKAAATLQS NGTDFDKRLK KLPESGLSAA
LLDSAQTLGT ETLLSTVCKL CGECQSNLAT EQVNYEISVE TEFINPLQTI CDVDIPSIIK
LRKALNKSTL DMDSAKSRFS QAVRQSQVPG ANMTTAAAKA ETIKEEYEEA TLKVETIKDN
LSIELCNFAA KESDQSQKML LLLEAQADYH RKALQAIEQF IPLVKVKIDN APCKPVYGMP
LEEHLRLMKR DISLVIEACV TVLLECGLEE EGLFRIAGAA IKLKKLKACF DAQSLDMEEF
SNDPHTVAGA LKQYLRELPE PLLTFAMHDE FLKAATLPLD QRLQTLWTLI QKLPVANFNN
FRYLVKFLAK LAEKSDINKM KPSNIAIVIG PNLLWSETSN APNMLTTGTL SAIIEAIVTH
ADWFFPGAFD FHLTALGSSP KPSTEPGLLS DSAQFVNNKT IDAPAKQDLD KKDNTAEKPL
CSKTRTLPLE QGFIVSSSDT YPLRFPEKCD EEESSSDESN PFSEKFALKS KTGESVSEKG
CMGKESDVQR VDLGDRKCDI SGSTNTGDYD NILYTINPLN PSARCSSMNP TDRRASADNV
SAYGKCLPAP VPPCRPSRPT KKPLPPEKTS CMPSGPRAEV SRSVDTLPDV AQPSSRYMIG
STPNITALPY HRNEEETYSG LQSQFWNRPN QKSNFNSLKR GSDPCIIPPP SQFNNYSTHR
PLKLSRAHLG TPPKPGEMSR SQPASHAENS RAPYSPPQEM SQSQPAPYVE KSPYSPPHEM
SLSQPSPSLK SPANHYNPVD KSFHQDTYNT AFALSSLGAG NKSADYLTRV RAMWDDRHQQ
LGTKPQNASH GKREELISSS LEFTPKQHPA TSYNNTNLVG SYQKNIFSSP STTNSGSSVP
YGRSTSCSPS QPPEFDFTTV GYHDDQETYN QSQTGTQQGS MESLQIQVTS AQSINQQPPS
PGVTVTNTSS QTTVINTQQE SPEAVSSIQR RATRKPAPPP PPEKPFTVMV TATTALKPGS
DMGFGEPEGN GSNAQFQTWP RSAPLASPES PSEQHKLSGG HEKRSSGERP TMPPPDRPER
PRLPQTLNPP LGRGHQRSAS TGAVMNQTAS SFEPHVGVPN AGSLTSSSIL EGDKDIDTIN
TGVGSETASY SQGSVAQGMS HTLGRHSSMK PRPTPPPPPP PVAKESEDTK L
//
