ID   A0A2C9KQ44_BIOGL        Unreviewed;       384 AA.
AC   A0A2C9KQ44;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=106077962 {ECO:0000313|EnsemblMetazoa:BGLB022293-PH};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB022293-PH, ECO:0000313|Proteomes:UP000076420};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGLB022293-PH}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB022293-PH};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   RefSeq; XP_013094129.1; XM_013238675.1.
DR   AlphaFoldDB; A0A2C9KQ44; -.
DR   EnsemblMetazoa; BGLB022293-RH; BGLB022293-PH; BGLB022293.
DR   VEuPathDB; VectorBase:BGLB022293; -.
DR   OrthoDB; 2952040at2759; -.
DR   Proteomes; UP000076420; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   PANTHER; PTHR11412:SF179; LD23292P; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
PE   4: Predicted;
FT   DOMAIN          22..169
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          268..358
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   384 AA;  42284 MW;  1E15F9800698AB89 CRC64;
     MNDNVFDSKT FTVYRTKSPL ALSILPLESQ TIRVGESALI KVNTSLPSYF DSTLAYLVMS
     QGNIVSAGQL KDNSFVITPT LEFCPLSRLL VYMIAGSESE NGEVVLDAVD LTLTGCFTKE
     VRVEFEASET RTGTEVEMKV DVSRLDGSNE MPGQHDVFYL AVDQSIVLLQ GSTDLNTDKV
     VSGLSSFDQV DESVTLSSAA AYFEHYQIKV AIDETLVVDN GQPPRFLAMA SRAGNGEDSL
     DFDTEVDGKV PEAAYQTSAR IRKDFPDTWL WGQAVTDVNG HLRSKVVLPD TITSWIVSAF
     AVNSEGLAVA KEPFKLTAFQ LFFLSMNLPY SIKRGEVFVL RVTVFNYRSQ HVQAVVSLAH
     SDQFMVVDET DSEGWYSKSL SVST
//