ID A0A2C9KV79_BIOGL Unreviewed; 1458 AA.
AC A0A2C9KV79;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=FYVE, RhoGEF and PH domain-containing protein 4 {ECO:0008006|Google:ProtNLM};
GN Name=106053183 {ECO:0000313|EnsemblMetazoa:BGLB023855-PC};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB023855-PC, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB023855-PC}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB023855-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR RefSeq; XP_013064132.1; XM_013208678.1.
DR STRING; 6526.A0A2C9KV79; -.
DR EnsemblMetazoa; BGLB023855-RC; BGLB023855-PC; BGLB023855.
DR GeneID; 106053183; -.
DR KEGG; bgt:106053183; -.
DR VEuPathDB; VectorBase:BGLB023855; -.
DR OrthoDB; 5385125at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF241; PROTEIN CBG10230; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 843..1031
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1196..1254
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1280..1377
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 261..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1382..1458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1383..1427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1458 AA; 162582 MW; 6120508E74E862D9 CRC64;
MYKRSTFLFP PIPEVENDGF PFAATEEEIR QFDKAFFHGK PAKPKKSWAK SFSEGTPLAS
LRRLQVPSRP KFIDKFLLGA SSLSRKSSGK LKKSPSVSSQ DSSKFYLDFQ EDQSDVGSTC
DSVSQCSSSF EGHSDHTGYL DVNCQGDDYD DEAALDEVVE DSDGGESSHT SLEICSQLNV
SSEDQSSELQ LKNHLHDYSV EEIIYDITDA EQQLITDAEQ QLITDAGQQF NSDHEHITKI
SCNSVEISDS QSVGALDIPA VSDSPTEAQE STSDSPTEAQ ESTSDEPPEP SLVTKGFVKR
QCQVFLQSLQ PSESARDSLD LSRKVKRSSS ELNPNSSLCG QYRRPLSPHS DNPDKWSKSL
YDISRNNKFT EAVMAKGYVK ALSEQINQQG ALKLEVDDDD AKKDALEESD EDAVFLHQFK
DQGLRQSFVK DLIQAAESQS SKENSSGNCK PPTVKKPGGY DQSPHSEHNS PSSVSCHNLS
SQTGINGDSS LNKSTSSNIN PTPKLFIKKT PENALSHSRS LHLSQSSSTT KHSPSKASSV
RSHSTTSPGD KPHVDYNSKP KKLSLTPELT QMLNVKADSP SESSLAHNES SVSKFSVTTN
TVGSPSEIKH SETHVAKHSE THVAKHSEIH VAKHSEMSEA KHIEIHLTYP NETSHKHADI
LVTKHNTTYV TTHSKTQTPK HTETQVSSPS SHPTSPISKS SNSSLPHPIS SPGTHIAALP
SELRMTSSNE SNKSCAGTQR EDSESSTSSS NSHNLEVSMR VSSTRSSQQY RDSVFNTIYD
NAPALNAAEL FDSSWSDSDS MDEFSDGEEK QEERKKVEEK KKKEEEKKEP SVSEQVDVPA
EDKRFRIASE LLQTERDYVA RLHLLHQVFY FTLDKENRQQ QMFPPDTLRH MFSNTKSIFL
FHNDFLLPQL EDRMKNWNAD PRIGDLMKKN APFLKMYTEY IRNFDRAMKL INQWMEKSVR
FSEIIRDIQK KPECGSLSLQ HHMLGPIQRV PRYELLLKDY VKHLPENSPD KSDAKDALDL
VTKAACHSNE AMKKIETFHK LLDIYQSLRG DVPVDFISPT REFVTQGPVT KISARSGEKQ
PRQIILFNDM VLVCAYILGA YSVRSVLEVD SLEIKPGNNM HIPNTMMLRS KQKAVELLDE
NPSGELMGWK VKFEDVIANY KQRKRFIKSI DVTDDSSETN MPESCLGKTA PVWIPDDAAT
MCMLCQSTFN MVRRRHHCRS CGKLICKSCC KKAPLEYKKM KIDRVCVLCY DVIVNKRGAT
ETSSVVDKKK GVLQVKASDP GLLCGYMHCS TDNGVSWSKL WVSARNDFAL YTFRAHEDVS
AIGSLPLPGH EVECFGEYEN KQNVFGLKHK NKMVFFFQAD NDKKMKRWVS LLSKLVKAEL
PEESSRLSSQ SNTSNTSSDN IATEGGNNRN STHSGSQADS GYPGDSNSSL AALAAEDIDH
ESADGVSQYD NIDAVVSE
//