ID   A0A2C9L7A7_BIOGL        Unreviewed;       360 AA.
AC   A0A2C9L7A7;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Peptidase M12B domain-containing protein {ECO:0000259|PROSITE:PS50215};
GN   Name=106052743 {ECO:0000313|EnsemblMetazoa:BGLB027865-PA};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB027865-PA, ECO:0000313|Proteomes:UP000076420};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGLB027865-PA}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB027865-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00276}.
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DR   RefSeq; XP_013063629.1; XM_013208175.1.
DR   AlphaFoldDB; A0A2C9L7A7; -.
DR   EnsemblMetazoa; BGLB027865-RA; BGLB027865-PA; BGLB027865.
DR   KEGG; bgt:106052743; -.
DR   VEuPathDB; VectorBase:BGLB027865; -.
DR   OrthoDB; 2939481at2759; -.
DR   Proteomes; UP000076420; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1620.60; -; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   InterPro; IPR041645; ADAMTS_CR_2.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR   PANTHER; PTHR11905:SF243; SOL NARAE, ISOFORM C; 1.
DR   Pfam; PF17771; ADAMTS_CR_2; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00276};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00276}.
FT   DOMAIN          25..141
FT                   /note="Peptidase M12B"
FT                   /evidence="ECO:0000259|PROSITE:PS50215"
FT   ACT_SITE        85
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT   BINDING         84
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT   BINDING         88
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT   BINDING         94
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
SQ   SEQUENCE   360 AA;  39888 MW;  2E9D5344FF068F83 CRC64;
     MNGDAASNSI EYFTVGAGRG IVGFYDHVML FTGYNLFRVD SNYNKKDTLG VTNSESMCRT
     DGRSSSVIED RKGYSTTTID TVAHELAHSL SAKHDGEDNT CKASKRYIMG SSELKKRPGT
     EYNPWRFSSC SVKYFTSFLK EKMKTSRGYT CLVYAIEASA DIPDVSDKLL GQLVKPDQQC
     QQLYGNNSYY CRASEAKSSL SDICLSMLCA DFSKKICSPQ RALMGTSCGD GKICINGHCV
     SDPYAPQLDE NCAFGDRPNY SCNMYISLFK GNCYSTGRYQ SCCDTCNNVS RPVKGCEYGD
     RILYCTQDHC LNAKEDCCGT CNYGNPFTPM SSTRRSTPIR LATTANPRVI FTPIKGRELC
//