ID A0A2C9LBU4_BIOGL Unreviewed; 513 AA.
AC A0A2C9LBU4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
GN Name=106077380 {ECO:0000313|EnsemblMetazoa:BGLB029196-PA};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB029196-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB029196-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB029196-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR RefSeq; XP_013093601.1; XM_013238147.1.
DR STRING; 6526.A0A2C9LBU4; -.
DR EnsemblMetazoa; BGLB029196-RA; BGLB029196-PA; BGLB029196.
DR VEuPathDB; VectorBase:BGLB029196; -.
DR OrthoDB; 2876972at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00812; LeuRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR002302; Leu-tRNA-ligase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR PANTHER; PTHR43740:SF2; LEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43740; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00133; tRNA-synt_1; 3.
DR PRINTS; PR00985; TRNASYNTHLEU.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035}.
FT DOMAIN 12..196
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 300..455
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 482..511
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
SQ SEQUENCE 513 AA; 58800 MW; F73B95E69FA7A5D0 CRC64;
LKDKCYVLSM FPYPSGSIHM GHVRNYVIGD IIARYKRSLG FEVLNPIGWD AFGLPAENAA
IGNKISPKVW TNNNINEMRE QLKRIGISYD WGKELATCSP DYFGQEQLFF IKMLAHGLVY
KKDEFVNWDP VDCTVLANEQ VVNGKGWRSG AVVERIKLSQ WFVRASKYSE DLLESLKXFK
KWPENVISMQ RNWIGKASGV KIKFFTENDN NECIEVFTDY PELLQELSFV AVSFEHSFVE
NLRHGTNAML GCPSSGEIDL NFIKKYNIKT NQLNDLLSKE DAIEYIEKLS IGIKCDNYSL
RDWGVSRQRY WGCPIPIIYC DDCGIVPVPE SDLPVLLPDD VDFDKNGNPL ASHKNWKNVL
CPKCGKMSTR ETDTLDTFFE SSWYFMAFCS FGSRFSDDDC KKWLPVDHYI GGIEHAILHL
LYSRVFCRMM KDIGYFGVPK EPFDSLLTQG MVCHSTFSDK NGNWLFPKDA KNRSDVIVGP
SEKMSKSKKN VVDPCYILDQ YGPDTIRFFI VSD
//
