ID A0A2C9LE28_BIOGL Unreviewed; 730 AA.
AC A0A2C9LE28;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Ferric-chelate reductase 1 {ECO:0008006|Google:ProtNLM};
GN Name=106060384 {ECO:0000313|EnsemblMetazoa:BGLB029975-PA};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB029975-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB029975-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB029975-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FRRS1 family.
CC {ECO:0000256|ARBA:ARBA00009195}.
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DR RefSeq; XP_013073678.1; XM_013218224.1.
DR AlphaFoldDB; A0A2C9LE28; -.
DR STRING; 6526.A0A2C9LE28; -.
DR EnsemblMetazoa; BGLB029975-RA; BGLB029975-PA; BGLB029975.
DR KEGG; bgt:106060384; -.
DR VEuPathDB; VectorBase:BGLB029975; -.
DR OrthoDB; 2908958at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08760; Cyt_b561_FRRS1_like; 1.
DR CDD; cd09628; DOMON_SDR_2_like; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 1.20.120.1770; -; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR InterPro; IPR005018; DOMON_domain.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR PANTHER; PTHR45828; CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE; 1.
DR PANTHER; PTHR45828:SF33; REELIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF03188; Cytochrom_B561; 1.
DR Pfam; PF03351; DOMON; 2.
DR Pfam; PF02014; Reeler; 1.
DR SMART; SM00665; B561; 1.
DR SMART; SM00664; DoH; 2.
DR PROSITE; PS50939; CYTOCHROME_B561; 1.
DR PROSITE; PS50836; DOMON; 2.
DR PROSITE; PS51019; REELIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..730
FT /note="Ferric-chelate reductase 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012112683"
FT TRANSMEM 579..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..173
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 192..307
FT /note="DOMON"
FT /evidence="ECO:0000259|PROSITE:PS50836"
FT DOMAIN 414..534
FT /note="DOMON"
FT /evidence="ECO:0000259|PROSITE:PS50836"
FT DOMAIN 538..730
FT /note="Cytochrome b561"
FT /evidence="ECO:0000259|PROSITE:PS50939"
SQ SEQUENCE 730 AA; 80136 MW; 38D7B03ABC111B4B CRC64;
MLRIYVSVFV FSVIIQSVCS YPTGAHNSAC THVTPETGHH KSTAGNVNPF FLKFSKHYYS
HGDKIQVTLS GGQFNGFLIV ARKTTDDAKN VGTFTDLLSE AKLTCDPTTG RGVTQTNANP
KNSVTVNWVA PTDTTDDIVF KYSVVLDIAS NYFANLNSTI LRYASPLQGK FYKDSECGRS
RGCYSNCLHD ICDLETSWQD KGDNIEISLT AVLNNDGYVS LGFSNASLMG PATVYYCTLN
NGSVSVIPGL TFGHRHTESN LSTSGISNEV SNYTDGILKC RFTVQKESSD PALFNLTDPW
YLNAAKGPIQ GDSLRFHGRI DRNVTSYRVN LSDVLTDEHF QPAVTSTAAT SQTTSSATRA
TMTTLTNTAT LTDTALTATA LTASTKSSVV TPSGADAECG STKGCFDNCN NGKCDLFVSW
ISKGEQIEFS LNTTTGHNGD YYLAVGFSET GKMGKASVVA CTVNQDSIID VYVSYNDDAY
NNKQMKDLKT AVKLISGSYK DGVLQCTFTR VASIANNSYF FDLNEPWYFI TARGPATLGG
EIQLHDSKYM SQSQIEFRVA RSYSLEVTKY PLIKAHGCLM VIAWMLLASI GLGFARFLKP
LWPSSMPCGV KVWFAMHRAF MVLAFLCGCA GFIIIFIQVK EYSTIVGAFY TKAHPILGII
TTALLVINPF MSLLRCAPDN PRRPYFNWAH RAAGTISHIL ASKWTFLKFS SFDFKANATH
TQRVYDQYQQ
//
