ID A0A2C9LEY9_BIOGL Unreviewed; 400 AA.
AC A0A2C9LEY9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Neurotransmitter-gated ion-channel ligand-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=106058831 {ECO:0000313|EnsemblMetazoa:BGLB030357-PA};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB030357-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB030357-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB030357-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU000687}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013071793.1; XM_013216339.1.
DR AlphaFoldDB; A0A2C9LEY9; -.
DR STRING; 6526.A0A2C9LEY9; -.
DR EnsemblMetazoa; BGLB030357-RA; BGLB030357-PA; BGLB030357.
DR KEGG; bgt:106058831; -.
DR VEuPathDB; VectorBase:BGLB030357; -.
DR OrthoDB; 2958160at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18989; LGIC_ECD_cation; 1.
DR CDD; cd19051; LGIC_TM_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF943; NICOTINIC ACETYLCHOLINE RECEPTOR BETA 3 (DBETA3) SUBUNIT; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 19..400
FT /note="Neurotransmitter-gated ion-channel ligand-binding
FT domain-containing protein"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5022259892"
FT TRANSMEM 230..253
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 297..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 378..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 25..210
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 236..334
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 400 AA; 45558 MW; B1E050CA98284A82 CRC64;
MVLLLMFFCV IFIEGVNTVG VTEMERLYSD LFARYNPEVR PSLSSSQTTE VTVQMSLAHI
MDLDIKQQVL HLIGFVSLRW TDQKLTWTPG MYGGIDHLFV RQNQVWKPDI AVINSVSDKV
YVGDKEVLVV VTSNGSVTWE PVINMQVTCQ VNILKYPFDE SICGLELTSW MYSEDSVPLR
ITKTPLRMVM AEHSQYRVKF HNAEIFKINH HGAFYTKLNF LFKLSRRASY LVLILVLPVT
LLAILCVVSF MLSPEVPEKT SLAITILLAY TVYLDIVDKE LPEISVQISH FVKYLTVLLF
LSFFCVTGNA IVFVVHKRGK ARELATQEVT SVTHYSDDST VKPSPNQSSF HSADVNMSEC
KGRRLQWRHK TKAEKMNFIF LVLNSVLLAL AISGYFFSVL
//