ID A0A2C9LPA1_BIOGL Unreviewed; 363 AA.
AC A0A2C9LPA1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Vacuolar protein sorting-associated protein 37A-like {ECO:0000313|RefSeq:XP_055895539.1, ECO:0000313|RefSeq:XP_055895540.1};
GN Name=106075977 {ECO:0000313|EnsemblMetazoa:BGLB033478-PA};
GN Synonyms=LOC106075977 {ECO:0000313|RefSeq:XP_055895539.1,
GN ECO:0000313|RefSeq:XP_055895540.1, ECO:0000313|RefSeq:XP_055895541.1,
GN ECO:0000313|RefSeq:XP_055895542.1, ECO:0000313|RefSeq:XP_055895543.1,
GN ECO:0000313|RefSeq:XP_055895544.1, ECO:0000313|RefSeq:XP_055895545.1,
GN ECO:0000313|RefSeq:XP_055895546.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB033478-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB033478-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB033478-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_055895539.1, ECO:0000313|RefSeq:XP_055895540.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
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DR RefSeq; XP_013092320.1; XM_013236866.1.
DR RefSeq; XP_055895539.1; XM_056039564.1.
DR RefSeq; XP_055895540.1; XM_056039565.1.
DR RefSeq; XP_055895541.1; XM_056039566.1.
DR RefSeq; XP_055895542.1; XM_056039567.1.
DR RefSeq; XP_055895543.1; XM_056039568.1.
DR RefSeq; XP_055895544.1; XM_056039569.1.
DR RefSeq; XP_055895545.1; XM_056039570.1.
DR RefSeq; XP_055895546.1; XM_056039571.1.
DR AlphaFoldDB; A0A2C9LPA1; -.
DR STRING; 6526.A0A2C9LPA1; -.
DR EnsemblMetazoa; BGLB033478-RA; BGLB033478-PA; BGLB033478.
DR KEGG; bgt:106075977; -.
DR VEuPathDB; VectorBase:BGLB033478; -.
DR OrthoDB; 3677578at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR Proteomes; UP001165740; Chromosome 8.
DR GO; GO:0000813; C:ESCRT I complex; IEA:UniProt.
DR GO; GO:0009056; P:catabolic process; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009851; Mod_r.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR PANTHER; PTHR13678:SF2; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A; 1.
DR Pfam; PF07200; Mod_r; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP001165740};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 277..363
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
SQ SEQUENCE 363 AA; 40407 MW; 38D4DB51E244BB02 CRC64;
MMKMNRLFGG GKHKGQATNL QAQRAKQIES LKKLGAHEIL KDTEYRVVTQ QGGTNLTLQI
NLPAQFPSEK PILTVQPAVT HPWVDLQMKV VGCPNINNFS MHSDLGQAVQ AVLEEFKKSP
PAIVPQHYIL GSSNPTIGSA VTKPGGPLPS YPGFNAYPGS QPSAIPPPLP PRRPPSGVGD
LGLDQLTLGS IEVAKILSEF PALKDMKIHE LNELSEDEDK IMEMIQKAPD LGKFIQQREA
LASTCVQLAQ SNLSKKSEIE NLRKILLAKS AELDNLKIEF ENHCERHMSL SDEYHPSHIQ
TNLKVAVMEA DEESEVVAEK FLDKELDVDE FLKSFMEKRT LCHLRRAKEE KLNQIILSQG
LRY
//
