ID   A0A2C9LSB7_BIOGL        Unreviewed;       685 AA.
AC   A0A2C9LSB7;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   13-SEP-2023, entry version 21.
DE   RecName: Full=FERM domain-containing protein {ECO:0000259|PROSITE:PS50057};
GN   Name=106073548 {ECO:0000313|EnsemblMetazoa:BGLB034284-PA};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB034284-PA, ECO:0000313|Proteomes:UP000076420};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGLB034284-PA}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB034284-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   RefSeq; XP_013089646.1; XM_013234192.1.
DR   AlphaFoldDB; A0A2C9LSB7; -.
DR   EnsemblMetazoa; BGLB034284-RA; BGLB034284-PA; BGLB034284.
DR   VEuPathDB; VectorBase:BGLB034284; -.
DR   OrthoDB; 2912597at2759; -.
DR   Proteomes; UP000076420; Unassembled WGS sequence.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd17102; FERM_F1_FRMD3; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR000798; Ez/rad/moesin-like.
DR   InterPro; IPR014847; FA.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR   PANTHER; PTHR23280:SF32; FI22325P1; 1.
DR   Pfam; PF08736; FA; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01195; FA; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        561..585
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        629..651
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          16..323
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   REGION          356..386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..383
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  78668 MW;  F454A5A67E8B64E7 CRC64;
     MSVFRKRSKS DAQTEYTCNI RFLDDTETIQ LTFKKDTLGQ WLFDRVCEKL NLVEKDYFGL
     RYVDTENQRH WLDPLKSVYR QLKGLNKMVL CFRVKFYPED PMKLHEEITR YYLFLQLRRD
     LHHGRLLCPH DESIQLAAYI IQSEVGDYDP QDHLPGYVSE FKMLPKQTPK HEEKIMEAHK
     ALAGEVPADC EANFLRKAAS MDTYGVDPHQ VKDQRGDPLY LGVTHLGIMT FRGSRRTQLF
     KWNQIRRIAY EGKMFIIIYS GSEEEDAGSS KKDLNIAAVT LCFRDVKRKK KHQTVGYKCL
     TAPAAKYLWR CAVEQQLFFT LSSSATAPKI RSGGSLFSRG SKFRFSGRCQ NEAYEASENI
     HRSEPPFART SSLPNFGKRN HGNEKNNTLI RDSRTTESFR EDRRKYNEAA IDVPSSIVLG
     ESPAITPTKE EVIEAGPQVK APLASVEAFE EKIQKTVSAP VTAAQPPPAY KENGQVVKER
     PAVLETSIDE TLPYEPNNTL EDSDEDRLVD KPNLDEQIKQ LEEEIINPSF QKDLNLSPPE
     AVQPVAKETP KKEPVKTSSG VCVKAVMISV VIMLLLSMAL FYVVFFSPIK HPIISKMRHS
     LAFLEPVKDL LIHKTNQVVG YFKNKLSFFF WWINILIYFL LSSFLPARLL VRSGQLQPSI
     CCDFSFEFFY TYFIQICKDL SSYSH
//