ID A0A2C9LSN1_BIOGL Unreviewed; 1897 AA.
AC A0A2C9LSN1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
GN Name=106055852 {ECO:0000313|EnsemblMetazoa:BGLB034544-PA};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB034544-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB034544-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB034544-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR RefSeq; XP_013067792.1; XM_013212338.1.
DR STRING; 6526.A0A2C9LSN1; -.
DR EnsemblMetazoa; BGLB034544-RA; BGLB034544-PA; BGLB034544.
DR KEGG; bgt:106055852; -.
DR VEuPathDB; VectorBase:BGLB034544; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1897
FT /note="Mediator of RNA polymerase II transcription subunit
FT 13"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012790562"
FT TRANSMEM 1528..1551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1571..1590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1192..1457
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1554..1886
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 212..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..338
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..503
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1897 AA; 209122 MW; 9D5BBE4DB730329B CRC64;
FFFVSAVILA PHGLCGVLTG VTYSENDHNP TSAKMFQDWS DYYPIKEDSL NKMPNMVEVI
VGGTRMRYPT CYVLVCDNED INGSNSVLQP LQTSILPGHN RSLTRSVSQF SPPASPIDPS
MGLDHHGIKI APLVGAVPGQ TESSQTISDS KADSISFHIA EKVRQDACIH VSQNKRLSEV
LSSEDQSHQP NVGVWNYTDP ASKVTCNCVR HRKKAQGKNA PGGKHGKGDK NDKMDRQLSR
LSRNPVPYHR RGHQLDDLLQ FDVERVMTQP NPAFSSTGAT TIVSSSNTTP QGRSSTPMHD
NVVPMDTPNS APSPLDEPQP PASSTLDPTM PTLSPHPPSK FLPDGSGGRP LNSVAGVGGA
VLPTDTNHLA APPGAVNIVG NSTVVLGSNN LNNNSTAGNV GSNTNISVTC AGSLISSTVN
SAMNGVTVLV DSNCKLAGED TSTSATAKMN SALSCMPVTP DSQQFSWSSV TSKTESVSHW
VHSHQQRPSS EKQHERHFDT NLKRPSLPTK GSDSDTEQGM ESLYNFDSLN MWIDLPLKKG
RYDLSDSLSG DLIAPSSSFA THSRATPMIK SPEDIYEFSD EASKDPKTVT IRSRPSRDDR
SSPLGKMDDD SRPSSRQGVA DVTIKEEATN GETELGHLTS PLTPGGSLTR ERDIRVVGAD
QDLAHIFQSD SEEDDDGGAP DSGIGTKSTD DLKPTRILNG TLGIIRTFFF YSSKYSVVVF
FIYMCIQLDS RQSLNIVAFH NSVENSLPPI VETITNIKCD VFVPPVVAET IGASKYSAVE
LPSGRSSPLP TVPEYKSSCC PIPPVDLQNS QKMHYINVPS IENISSIRTV GSGIDASPAI
YSNSQQRTPL SYELTSPASN SSSYLNKTNN SIDNHGTNGQ LPEAHSLLLN VLLCDSILNL
FKDHNFDSCT ICVCNADING SDVSVYLPDT SKGSSSGFKC SCAFSAAVNR RFGYNSGLFY
EDEIEITGFR HDHYDHRKTP LMQSNDPSKS NGDPLKLDDI TPQVMNQLLG QYASPFISCI
GSHHINLLQM STDLSHQLST VDTLQIRDAN EVVCQALEIA RQAMDHCFGF ARYDDPILKG
NFLHKWPYLR GPGCVPSSTQ ETIQCLKSLH PILQTAIQNK RVTRLWENTY TLQGPISWKD
FHDLAGRGTE ENHEPQPIPH FLVGHDRDWL TVSPYSIRFW DKQFLEPYGR MRDVLYVVVA
PDNDFILQHV VSFFKELSTV YEMCRLGRHC AINKPLRDGV LRVGKSAATK LMDEPVEDWF
NFLGDSSIAS KLKLYAQVCK HNLGPILCQT NWDKSMFEQG SSSSHKAQFK MPEPASNTTR
PVTPDNQQSS GHPTGAAQGG QLSEEVKDGM PTDGSAQQKE NQHDNVEGAG EDTNTEAPGI
VVYLVDPFSY GQDGESVSRL AMIGLLRCYQ QMALPEHLAN NLSLQLVPLR TILEHKDSAN
KLQTLKSIAF SVFTSCKWNI GYSIMGRSLT GFGPAAAAEQ FLKRKGVRVL SPSVLQESIY
IYKNTFFFLW IGFRSVKHSM SYVKFKFVFM FHCYNSTVNV VYFVDIMILF YVPFRNRRKK
ASARRPGLQK LWDFILSVVS LTCYPTRLVI GRFGRMGHGE LKGWSGLLSK KNLHSASRRL
KDMCGQCSVM GPSEVPCVLS VCLTSIETHP SFQVVADTLK PEEKQSSSIP LQTPRDASVT
HILVFPTSAT AQVNANPLQQ DPQNDLTAHF ELDDVFVDIH QMGEDMGFLD IFGETFDNPP
TSPPGSPISN ANRQNLRMNG PSTSMIENQS DPQDDCNLLQ QPLAMGYYIS TAPPGPLPKW
FWSACPENEF VSPHVFKSAL HIHESSRHDD ILHKTDNRNK PHALDSHMTC DVLRYVLENY
NSLSWLTFDP VLNDRRSCLP VHFVVLMQLY HALQTFV
//
