ID A0A2C9LU20_BIOGL Unreviewed; 264 AA.
AC A0A2C9LU20;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Vacuolar protein sorting-associated protein 37B-like {ECO:0000313|RefSeq:XP_013068218.1, ECO:0000313|RefSeq:XP_013068219.1};
GN Name=106056160 {ECO:0000313|EnsemblMetazoa:BGLB034983-PA};
GN Synonyms=LOC106056160 {ECO:0000313|RefSeq:XP_013068218.1,
GN ECO:0000313|RefSeq:XP_013068219.1, ECO:0000313|RefSeq:XP_055862035.1};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB034983-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB034983-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB034983-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_013068218.1, ECO:0000313|RefSeq:XP_013068219.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013068218.1; XM_013212764.2.
DR RefSeq; XP_013068219.1; XM_013212765.2.
DR RefSeq; XP_055862035.1; XM_056006060.1.
DR STRING; 6526.A0A2C9LU20; -.
DR EnsemblMetazoa; BGLB034983-RA; BGLB034983-PA; BGLB034983.
DR EnsemblMetazoa; BGLB034983-RB; BGLB034983-PB; BGLB034983.
DR GeneID; 106056160; -.
DR KEGG; bgt:106056160; -.
DR VEuPathDB; VectorBase:BGLB034983; -.
DR OrthoDB; 2918090at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR Proteomes; UP001165740; Chromosome 12.
DR GO; GO:0000813; C:ESCRT I complex; IEA:UniProt.
DR GO; GO:0009056; P:catabolic process; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR InterPro; IPR009851; Mod_r.
DR PANTHER; PTHR13678:SF27; LD45836P; 1.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR Pfam; PF07200; Mod_r; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP001165740};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 124..213
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
FT REGION 208..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..253
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 29081 MW; EE8418A01FF1759D CRC64;
MYHNYVSAGY GGGVTNPYAQ QPYYSPPSFG PDPPSSALSN INEQAATALL KHLDRHELED
LLQNDSKLQS LIDDLPQVKA LQVEHDNLVV TTKSLAEYNL SLQPKLESLK QDVAERYQRA
NSLRTGLIEQ KAVLDSLTDR QSLDTVLALL QTETAKTEEE SEELADGFCE GRLAAEEFLA
QYLPKRTQAH IRRIKSERFA ELIRNGPSAV TTTSIPPANS WGATHAQPTN SAPYPTQVPR
GPAPKPPYPI GAGYGMPQPS LYNR
//
