ID A0A2C9LYZ7_BIOGL Unreviewed; 1069 AA.
AC A0A2C9LYZ7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 {ECO:0008006|Google:ProtNLM};
GN Name=106067962 {ECO:0000313|EnsemblMetazoa:BGLB036629-PC};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB036629-PC, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB036629-PC}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB036629-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR RefSeq; XP_013082688.1; XM_013227234.1.
DR AlphaFoldDB; A0A2C9LYZ7; -.
DR EnsemblMetazoa; BGLB036629-RC; BGLB036629-PC; BGLB036629.
DR VEuPathDB; VectorBase:BGLB036629; -.
DR OrthoDB; 4835at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17113; RA_ARAPs; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR PANTHER; PTHR45899:SF2; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 4.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 3.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 99..200
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 214..305
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 311..438
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 515..613
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 714..912
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 121856 MW; D4757E93B1C25AA1 CRC64;
MDEMLEASPP APHHAAGLCQ SPLSRTLSSS STSSSLADSD LYVNLGCGEN RRLYSVDSTT
SLSVRSEISS DSEGSEEQMP PWQNIRPEAH IAEPMSSRKN SRDGYLLKQG GHNANRGWRR
RWVVFNGASL SYYSDNTSQV SIRIIPIKCM TEVEADIKPT DKDNFRFKLH TTLKNRIFLF
ASDTRDDCLN WALTLGAAIT EYKKLPVREV QPEKPDKEGF VRINSSSKKY YVSITGPTLQ
YYHSLEDYHI GSPIHQIDMK LASVKVKERK KCKLQLATHY RYFEFTFDDD SEMQNWYMAM
EDAIAEGLAD DTVLEKVYDN LSNKNCADCG AENPHWASIN LGIVVCKNCA GVHRAFDYRV
SKIKSLRMDT RVWTPSLIEL MVTIGNANAN AFWEFTLPPG MKAQPKDSME KRKEYITKKY
IGKKFSNLHE LHSMGPQALG KELVSVAGSA DVLDLMKILF SGAQVLYRIN NCGQTAYEVA
KDSGQRLNME LLYQNSGDPQ SQLESVSDEN RLREDIRLQG YLNKTGPMRG KFESRWCVLE
HGSLTYYANE KSTTFKGTID RKEMCMIQSV ESDKIGYHFD LSTTMKENRI FSFSSDCKED
AGEWIRTIAK LMAPIAVMEH VGMIDIKFAG AAHMRESLSQ DWQQTFLVFS WRGLNYMNRD
LKFDYLDLRK ASGIKKQLTG DGYQKQGPYF VISSTVKSVY IQATLPRDTE QMFLALSQAI
SESGRTLHDQ PLTSKSVPVI VDKCIAYITT HGLKEKGIYR QTGQLSRVQT LLDEFRKDAH
SVVLTNYTVH EVAGALKKFL RELDDSVFER NNYGNWIEAA GSKDEQHRMG LYKYYLGRMP
EVNRQTLKAV ILHLLDVAQN EHENSMSITN LATCFAPSLL RTQLDELQFA SETASREISI
ILDILKNRDF FFKVDEKDTI VENNIRDALL KMKKGSIKGS TDNVNTPSCM LTPVLLLGES
DHSVNISVTP EKTVQDGLIE ALANFRRNNR NLEIRNYILE EQLFDGMLER PLFNEELISK
TTVRWLEWSS FYDRGINTRL CLRNTDIMEN LKKSVRLEFF LQRKCSDIT
//
