ID A0A2C9LZ78_BIOGL Unreviewed; 284 AA.
AC A0A2C9LZ78;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 13-SEP-2023, entry version 22.
DE RecName: Full=Cysteine dioxygenase {ECO:0000256|ARBA:ARBA00013133, ECO:0000256|RuleBase:RU366010};
DE EC=1.13.11.20 {ECO:0000256|ARBA:ARBA00013133, ECO:0000256|RuleBase:RU366010};
GN Name=106076010 {ECO:0000313|EnsemblMetazoa:BGLB036700-PA};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB036700-PA, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB036700-PA}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB036700-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-cysteine + O2 = 3-sulfino-L-alanine + H(+);
CC Xref=Rhea:RHEA:20441, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:35235, ChEBI:CHEBI:61085; EC=1.13.11.20;
CC Evidence={ECO:0000256|RuleBase:RU366010};
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|RuleBase:RU366010};
CC Note=Binds 1 Fe cation per subunit. {ECO:0000256|RuleBase:RU366010};
CC -!- PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine
CC from L-cysteine: step 1/2. {ECO:0000256|ARBA:ARBA00004759,
CC ECO:0000256|RuleBase:RU366010}.
CC -!- SIMILARITY: Belongs to the cysteine dioxygenase family.
CC {ECO:0000256|ARBA:ARBA00006622, ECO:0000256|RuleBase:RU366010}.
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DR RefSeq; XP_013092357.1; XM_013236903.1.
DR AlphaFoldDB; A0A2C9LZ78; -.
DR EnsemblMetazoa; BGLB036700-RA; BGLB036700-PA; BGLB036700.
DR KEGG; bgt:106076010; -.
DR VEuPathDB; VectorBase:BGLB036700; -.
DR UniPathway; UPA00012; UER00537.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0017172; F:cysteine dioxygenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042412; P:taurine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR010300; CDO_1.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR Pfam; PF05995; CDO_I; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|RuleBase:RU366010};
KW Iron {ECO:0000256|RuleBase:RU366010}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU366010};
KW Oxidoreductase {ECO:0000256|RuleBase:RU366010};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 156..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 284 AA; 32380 MW; 6830A051A8428001 CRC64;
MSLDQLNKLL SAVLPVVLHG ELREILYTAG NAFSKNEHVY KVGDVSWTVV LNESEWHEVK
NNDSSSRAVS LHIYFKPTDK NQVFGEEEPR TLEHISEKGK PKDTKCLPLS DDPRYIRECY
WETDDVHDTR TVNRLECLYG FCVPKERKVS ALRERLFLIA AVISFVIALV ALLLVTLTIK
NEQENTVSSK SRFEICLNCS LLFLPTGHPV EREITITYSS DTREKCCAEN EQELSILMDL
ILNASQVRTN EELSSFTKEK LPISAHKRLM QTNLPGQGKD KNLP
//
