ID   A0A2C9M3E9_BIOGL        Unreviewed;       314 AA.
AC   A0A2C9M3E9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:BGLB037968-PA};
GN   Name=106074934 {ECO:0000313|EnsemblMetazoa:BGLB037968-PA};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB037968-PA, ECO:0000313|Proteomes:UP000076420};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGLB037968-PA}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB037968-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR634016-3};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR634016-3};
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DR   RefSeq; XP_013091282.1; XM_013235828.1.
DR   AlphaFoldDB; A0A2C9M3E9; -.
DR   STRING; 6526.A0A2C9M3E9; -.
DR   EnsemblMetazoa; BGLB037968-RA; BGLB037968-PA; BGLB037968.
DR   KEGG; bgt:106074934; -.
DR   VEuPathDB; VectorBase:BGLB037968; -.
DR   OrthoDB; 3085317at2759; -.
DR   Proteomes; UP000076420; Unassembled WGS sequence.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd09601; M1_APN-Q_like; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 3.
DR   Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR   InterPro; IPR045357; Aminopeptidase_N-like_N.
DR   InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR   InterPro; IPR034016; M1_APN-typ.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   PANTHER; PTHR11533:SF276; AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   Pfam; PF17900; Peptidase_M1_N; 1.
DR   SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 2.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR634016-3};
KW   Zinc {ECO:0000256|PIRSR:PIRSR634016-3}.
FT   DOMAIN          1..61
FT                   /note="Aminopeptidase N-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17900"
FT   DOMAIN          164..270
FT                   /note="Peptidase M1 membrane alanine aminopeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF01433"
FT   BINDING         146
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634016-3"
FT   BINDING         152
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634016-3"
FT   SITE            204
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634016-4"
SQ   SEQUENCE   314 AA;  35656 MW;  7208692181AA49E9 CRC64;
     MFPCFDEPAM KASFNVTLVR PIDMISLSNV ELLDSRETFL DGSITYVKDV FGQSAIMPTY
     LLVIAICDFT YLNATTNKGK EFRTYAVPAL VNSTKYSLDI GVKILDYLEE FFNISYPLPK
     LVQYMYTALA NDGLVSSHPL YVPVNHPDEI NEIFDSISYS KFDTYVVQYM YTALANDGLV
     SSHPLYVPVN HPDEINEIFD SISYSKGAAV VRMMSHFLGF DVFKKGLTKY LETLAYKNAF
     HDDLWNFMTA AETAGADSRR IDVKEVMDTW ILQMNYPVVT VKRVDNSNTQ LLVSQARYLA
     DRNATELGKY ESPF
//