ID A0A2C9M7Y0_BIOGL Unreviewed; 1187 AA.
AC A0A2C9M7Y0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:BGLB039485-PC};
GN Name=106072408 {ECO:0000313|EnsemblMetazoa:BGLB039485-PC};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB039485-PC, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB039485-PC}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB039485-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_013088228.1; XM_013232774.1.
DR AlphaFoldDB; A0A2C9M7Y0; -.
DR STRING; 6526.A0A2C9M7Y0; -.
DR EnsemblMetazoa; BGLB039485-RC; BGLB039485-PC; BGLB039485.
DR KEGG; bgt:106072408; -.
DR VEuPathDB; VectorBase:BGLB039485; -.
DR OrthoDB; 2911572at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 2.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 19..1187
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5011813916"
FT TRANSMEM 1060..1082
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 1087..1107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 332..397
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 400..458
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 512..668
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 669..803
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 873..1011
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 847..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1187 AA; 131530 MW; BFA87BCA720BF23D CRC64;
MLLRDLLLCF GFRILVRARV RQSCCRQCNS DYTGHTRPAM RLRNVGLPPY ICMYSLLAII
SAHNVNVTNV RVITREDNFG GSFGYSGALY SSDIGTLDAM ISAPNSNSKK RGDEKTGQIL
KFTNIFSTQS LPEETIFYPS QTGLLNGSNG EGFGTTTLVI NSTHRLMCAP RWLNTTKIKE
KSPAFLGRCV LVGPGSDSIQ EFGPYAQAVG YFHHVPKNMY HKHVYWKGGS LFGFSADSDG
SVVAVGTPGL LNAKGGVHVY DIASGNMSDY NLTSYISNLN ATSYGYLGYS VKLGTFCNEG
YRGVCVAVGG PTMLNFGQVQ IIHWNKDDIF NKLIQEINGT QIWSSFGYCL GSVNINNNAY
DELLVGAPLY TEWSNPDHVP DQGMVFLYHY DLLTKKYIKR DVTLDGSRQK SARFGSAMAD
IGDINLDGVS DLAVGAPGET DGAGSIYIYL GSTNGFVNVP SQRIQASQIK VPVLLKGFGF
TISSQHAPLS NTYPVFAVSA VLTDTVVIFR CKPVVDVQVN LTASPNPIDL RSACSRDFNL
QGKCFKVQFC LIHAIRGSDF QPVNFSIHYF LDTHIQSEEL KRVTFPTGQG TTHSTVKTTV
LESASPNIPV CSELVVLLKL AQIQLDRFTP IEIKTTFQIQ PTHSPDDGPL LDALKANNIV
EEVTIKKECR SDVKCEVDLI VSATLQNSPI NTQWTDIIVN YTKQVVMKIN IRNKNETAYG
VKITAEVDSI LTFVKSKPDV NCALESIELN TTGIDLADTE KTLVTCISYE ALSPKDELEF
HIVFDINQTY INNDIINKDL NAKVSTTPYN YEHSPEINVD DNAILLTGHV NIASILEISS
ISSPKEIAMQ RTERKSDGEP VVTGGDQQRT PINVTHKFLV QNKGPSYLPR TEIVVRVPHL
LDDRSELVAN ITVEMLTPSG KVQCTSSDQI TSTTPDFPTT YSTTTVDWVI ENKRRRRSVQ
NKCQEKLCFL KCEDGPDLCS VHTCEVKTDL QPNSHMELNV NMDIDLAKLL IEKEFNTLHF
ISDIEIKEPK HLLLKLWRVT QQKESVTSFH FVQPGDQVNI WIIIGSLMAS LIVLAIVCVI
LWKVSLIVLA IVCVILWKVS LIVLAIVCHS VEGKLDCSRH HVCHSVEGKF DCSSHRVCHS
VEGKFDCSSH RVCHSVEGKL DCSRHHVCHS VEGWIFQTHP TFRASEG
//
