ID A0A2C9M9P9_BIOGL Unreviewed; 1722 AA.
AC A0A2C9M9P9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Kinesin-like protein unc-104 {ECO:0008006|Google:ProtNLM};
GN Name=106057456 {ECO:0000313|EnsemblMetazoa:BGLB040161-PJ};
OS Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Planorbidae; Biomphalaria.
OX NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB040161-PJ, ECO:0000313|Proteomes:UP000076420};
RN [1] {ECO:0000313|EnsemblMetazoa:BGLB040161-PJ}
RP IDENTIFICATION.
RC STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB040161-PJ};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR RefSeq; XP_013070106.1; XM_013214652.1.
DR EnsemblMetazoa; BGLB040161-RJ; BGLB040161-PJ; BGLB040161.
DR VEuPathDB; VectorBase:BGLB040161; -.
DR OrthoDB; 126886at2759; -.
DR Proteomes; UP000076420; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22705; FHA_KIF1; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 2.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 3..355
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1608..1706
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1085..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1513..1542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1562..1581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 625..674
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1095..1109
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1518..1542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1562..1577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1722 AA; 196038 MW; 0C80DBA2E91CA74E CRC64;
MSSVKVAVRV RPFNNREMSR EAECIIDMSG NTTTITNPKA GPKEAQNKSF NFDYSYWSHT
TPEDPNFADQ KKVYDDIGLE MLDHAFEGYN VCIFAYGQTG SGKSYTMMGK NEPGQEGIIP
QLCEDLFRRI SGQKNNDTTF SVEVSYFEIY CERVRDLLNP SNKNALRVRE HPLLGPYVED
LSKLAVQSFE DINNLIDEGN KARTVAATNM NETSSRSHAV FTIIFSQRRY DPDTKIVGEK
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEISS MDPKAKNKKK
KADFIPYRDS VLTWLLRENL GGNSKTAMVA ALSPADINYD ETLSTLRYAD RAKQIMCKAV
VNEDPNAKLI RELKEEVARL KDILTSEGIE LGEGQSMQEY LEQRGRSRSR KESVTLEGGD
DALERLKETE KLIAELNLSW EEKLHKTESI RKEREALLAE MGVALKEDGG TIGVFSPKKS
PHLVNLNEDP LMSECLLYYI KEGTTRVGLH DAEKPNDVQL SGSNILEEHC LFENIDGNVT
LIPCEGALCY VNGRQVTEPV KMKTGARVIL GKHHVFRFNH PQQARASRAL MSESMIESTD
NPITEPVDWT FAQLELLEKQ GIDLRKEMES RLMLLEEQYR KEKEEADLLF EQQRQDYENR
IQSLQEQVER HSMISSVATT NIFEEEEEEE EVHWSDREKD LAAWAFRKWK YHQFTSLRDD
LWGNAIFLKE ANAISVELNK KVQFQFVLLT DTLYSPLPAD LLPAEERDDS RPFPKTIVAV
EVQDTKNGAT HYWSLEKLRQ RLELMREMYH NEAELSPTSP EPNIDSMTGG DPFYDRFPWF
RLVGRAFVYL SNLFYPVPLV HRVAVVNDKG DVKGYLRVAV QAITDKDDPQ EYSAGVKQSG
NAKITFSDEE YFNKKQIQAT SFPLPPGMEK PVDTMVSSLE ELRIVEGEGQ TMDNSMLISE
NHLIESDNKT KGQYGKFDYC PEMNASDLPE HLTIGSQFQF RVTILQASNI SPEYADIFCQ
FNFLHRHDEA FSTEPLKNTG KGPPLGFYHV QNFTVTVTKS FIDYIKTQPL VFEVLGHYQQ
HPLHEQSKDC PYVRPPPSRS FPTMPVSKPV PSPKYGIIAP SSKSEEDEKD KNDDLERKKK
RKAQDSSSPV HSQCDLLVWF EICELAPNGE YVPVVVDHSE DLPTKGIFML HQGIQRRLRI
TIVHEKRTHF AWKDVRELVV GRIRNTQEFY DYDIETTVLS LGLFPAHFLQ YQNDDRVFFQ
FEAAWDSSLH NSPMLNRVTA YGEKVYMTLS AYLEVENCAQ PACITKDLCM VVHSRDTKIS
APSPRFRALK SLFGVARYPD CGKVSGIYEL LLRQYSDSGS PGVERRQRRV LDTSLTYVRG
EENLNGWRPR GDSLLGDHQW ELEKLARLQL VEKTRHVILL REKLAEQNKS HELSKLDKEI
VNRQAKNQKI QGYEHTEIKS DENPKDVDIK EKNVQILCRG ESFDLKTDGD PEKELAARCV
RLMLQGRLPL KPPPVKLDSM LSSTTTVTSE ESETSSDSLG TSLSSSMVSD IVKAVPIQSS
KSCDSLLTSS PSPSGESADR KLSLPIKTIN LDTPMFVPDI EEVRPSPVVS RRGYLNFLED
NTNGWIKKWV VVRRPYVYIF NNEKDPVVRG IINLATANIE YSEDQQALLK TQNAFSVMTK
HRCFLLQTLD DKDFHDWLYA INPLLAGQIR SKLSRRKQPM KI
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