ID   A0A2C9MAJ5_BIOGL        Unreviewed;      1490 AA.
AC   A0A2C9MAJ5;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Sema domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=106070840 {ECO:0000313|EnsemblMetazoa:BGLB040402-PD};
OS   Biomphalaria glabrata (Bloodfluke planorb) (Freshwater snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC   Planorbidae; Biomphalaria.
OX   NCBI_TaxID=6526 {ECO:0000313|EnsemblMetazoa:BGLB040402-PD, ECO:0000313|Proteomes:UP000076420};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGLB040402-PD}
RP   IDENTIFICATION.
RC   STRAIN=BB02 {ECO:0000313|EnsemblMetazoa:BGLB040402-PD};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   RefSeq; XP_013086271.1; XM_013230817.1.
DR   EnsemblMetazoa; BGLB040402-RD; BGLB040402-PD; BGLB040402.
DR   VEuPathDB; VectorBase:BGLB040402; -.
DR   OrthoDB; 2956345at2759; -.
DR   Proteomes; UP000076420; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR   CDD; cd12790; RasGAP_plexin_A; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR031148; Plexin.
DR   InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR   InterPro; IPR046800; Plexin_RBD.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR041019; TIG1_plexin.
DR   InterPro; IPR041362; TIG2_plexin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR22625; PLEXIN; 1.
DR   PANTHER; PTHR22625:SF69; PLEXIN A, ISOFORM A; 1.
DR   Pfam; PF08337; Plexin_cytopl; 1.
DR   Pfam; PF20170; Plexin_RBD; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01833; TIG; 3.
DR   Pfam; PF18020; TIG_2; 1.
DR   Pfam; PF17960; TIG_plexin; 1.
DR   SMART; SM00429; IPT; 3.
DR   SMART; SM00423; PSI; 3.
DR   SUPFAM; SSF81296; E set domains; 3.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        819..845
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          58..115
FT                   /note="PSI"
FT                   /evidence="ECO:0000259|SMART:SM00423"
FT   DOMAIN          215..250
FT                   /note="PSI"
FT                   /evidence="ECO:0000259|SMART:SM00423"
FT   DOMAIN          381..428
FT                   /note="PSI"
FT                   /evidence="ECO:0000259|SMART:SM00423"
FT   DOMAIN          429..522
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000259|SMART:SM00429"
FT   DOMAIN          523..613
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000259|SMART:SM00429"
FT   DOMAIN          615..710
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000259|SMART:SM00429"
FT   COILED          845..887
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1490 AA;  169058 MW;  3BA375D00BFCEE82 CRC64;
     MYLVCPQVSL DSNVTGNLYE QVTVTPNEAF LSDIFFDNQQ EHLYLLTSFR VVRMKVQNCT
     QYTSCGECLG AKDPYCGWCS LQSNGVRRNT CSLKSECNGS KYPNRWLSHT KQECPKIKQI
     LPEEISIDRE GLLTLNVQNV PDFQNQIFYI CQFTAFNTEH KIVRMANRTH NNFQCFTPEK
     SLLPPFETGK DSVSMKLSLL LNNTELVHDT VTFFNCAHHK VCTSCTMSKF PCSWCIKKHM
     CTDNTAQHCH GDTVISGQKI EKQFRMHNPG PEFCPKFENW NSSNEILVAA GSMTSISVRG
     VSLFDFQQDK LWCSFRVDNI TEVPARSVSI GQGRLFNISC DLHKFNYLKT ISRKTVVMEI
     LWGDGKHPLD NPSGLQIEVY KCSVMAGTCG ACLTAEEKYQ CVWCEGKTCK PAESCQNTHS
     LRKGNVCDNP HIKQLSPLSG PVGGGTLLTI IGENFVAAQN DLKVTIDGVM QVNCLVVEFS
     PPSRIVCEVQ RSNTYNLTFQ GIVHVSVGNR FRTEFPQKYE FVKPDLREIY PKFGPYDGGT
     VVTLSGLHLN SGSNISVHFG KNNPCREITR IDFAAISCKS SRVNESLFSK PVDVSVTIDK
     TALDTNGIQF HYVPNPNVTW LSRLQGFRSG GLSLNVSGHH LNSVQSPYFL IWYKGVPYSG
     ACAFPVSSAT NITCVTPLIQ DLNATFDGYE ELDFGFKMDE VSGLEKLTHM GKFKIFPDPN
     LYAFNDGKKV HKQSQEILLI NGVNLMPLKE LDIKVYIGKT ECLVMSISKI IITCTLPQNL
     PDTSDGSGSP EVIVQIGQNL TFNLGVLQFE EQEGLTQEAM IGIIVAVALT VVLIIIVGIC
     CYIKVRRNDD MMKKMRKDMD QLESRVANEC KEAFAELQTD MTELTSDLSG GCSIPFWDYR
     TYCMRVLFPP ECNDHPVIKE LELDYRHKED LEKGLKAFFN LIRNKTFLLI FVRTLENNQD
     FTMKERVNVA SLLSVSLQTQ MEYATEILKT LLAELIEKTV ENPKVHPKLL LRRNESVAEK
     MLTNWYTFLL YKFLKECAGE PLFMLYNAIK QQVSKGPVDA VTSEARYSLS EDKLIRQQVT
     FKSIVLHVMD IDVDRCSQPT HQVKVLDCDT ISQVKEKILD SMYKSAPFSS RPPKEELELE
     WLGEKSSIPL KIFPTKDTKR MVLSDEDHTT KMENDCKRLN TLSHYKVPDG AYVALHPKQT
     SMYNMSYVPD KHKYGSENSF YNRSPSLNRT LNGPLLANDS DCKVYHLVRH HDVDSNNKEG
     ERGSKLVSEI YLPRLLVTKG TLQTFVDDLF ERIFSTAHRG TALPLAIKYM FDFLDDQALH
     HNMSEEVVHT WKSNSLPLRF WVNVIKNPNF AFDIYKSNIV DACLTVIGQT FMDCCSTLEH
     KLTKDSPSGK LLYAKDIPKY KQWVARYYQD IKIMPAISDQ DMTAMLAEES RSHQNEFNTN
     AALLELYKYV KKYYDDIVNA LEDDEFAKKS KLTYKLDQVS TLMEGTTTIC
//